Gene interactions and pathways from curated databases and text-mining

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CEBPB — IL10

Text-mined interactions from Literome

Liu et al., J Immunol 2003 : In this study, we determined that, in addition to Sp1, C/EBPbeta and delta were also involved in LPS induced gene expression of IL-10 ... These results suggested that the interaction between Sp1 and C/EBPbeta and delta induced by LPS cooperatively activated expression of the IL-10 gene
Tanaka et al., Am J Respir Cell Mol Biol 2005 : Interleukin-10 induces inhibitory C/EBPbeta through STAT-3 and represses HIV-1 transcription in macrophages ... In contrast, in undifferentiated THP-1 monocytes, IL-10 did not inhibit HIV-1 replication or induce C/EBPbeta ... Differentiation induced post-transcriptional regulation is required to produce inhibitory C/EBPbeta in response to IL-10
Csóka et al., Blood 2007 : A2A adenosine receptors and C/EBPbeta are crucially required for IL-10 production by macrophages exposed to Escherichia coli
Qin et al., J Leukoc Biol 2010 : Bioinformatics analysis identified KSHV miRNA binding sites formiR-K12-3 and miR-K12-7 within the 3'UTR of the basic region/leucine zipper motif transcription factor C/EBPbeta , a known regulator of IL-6 and IL-10 transcriptional activation.Subsequent immunoblot analyses revealed that miR-K12-3 and miR-K12-7 preferentially reduce expression of C/EBPbeta p20 ( LIP ), an isoform of C/EBPbeta known to function as a negative transcription regulator