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IDO1 — IL18

Text-mined interactions from Literome

Liebau et al., Anticancer Res 2002 (Bone Neoplasms...) : Interleukin-12 and interleukin-18 induce indoleamine 2,3-dioxygenase (IDO) activity in human osteosarcoma cell lines independently from interferon-gamma ... The presented study demonstrates that IL-12 and IL-18 , or even more a combined application of both cytokines, induce IDO expression besides the known pathway via IFN-gamma
Spalletta et al., Mol Psychiatry 2006 (Brain Ischemia...) : The increased production of proinflammatory cytokines such as IL-1beta, TNF-alpha or IL-18 resulting from stroke may lead to an amplification of the inflammatory process, particularly in limbic areas, and widespread activation of indoleamine 2,3-dioxygenase (IDO) and subsequently to depletion of serotonin in paralimbic regions such as the ventral lateral frontal cortex, polar temporal cortex and basal ganglia