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GIP — SPP1

Text-mined interactions from Literome

Lyssenko et al., Diabetes 2011 (Diabetes Mellitus, Type 2) : Pleiotropic effects of GIP on islet function involve osteopontin
Omar et al., Biochem Biophys Res Commun 2012 : Regulation of the pro-inflammatory cytokine osteopontin by GIP in adipocytes -- a role for the transcription factor NFAT and phosphodiesterase 3B ... In this work we show that GIP stimulates lipogenesis and osteopontin expression in primary adipocytes ... The GIP induced increase in osteopontin expression was inhibited by the NFAT ( the transcription factor nuclear factor of activated T-cells ) inhibitor A-285222 ... To test whether cAMP might be involved in GIP mediated effects on osteopontin a number of strategies were used ... In summary, we delineate mechanisms by which GIP stimulates osteopontin in adipocytes
Ahlqvist et al., Diabetes 2013 (Insulin Resistance) : Since glucose dependent insulinotropic polypeptide ( GIP ) is a strong stimulator of adipogenesis and may play a role in the development of obesity, we explored whether GIP directly would stimulate OPN expression in adipose tissue and thereby induce insulin resistance ... GIP stimulated OPN protein expression in a dose dependent fashion in rat primary adipocytes