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EPHB2 — GAL
Text-mined interactions from Literome
Wittau et al., Oncogene 2000
(Calcium Signaling...) :
While phorbol ester induced extracellular signal regulated kinase ( ERK ) activation required protein kinase C ( PKC ) activity, preincubation of H69 cells with the PKC-inhibitor GF109203X had no effect on
galanin dependent
ERK activity ... A rise of the intracellular calcium concentration was necessary and sufficient to mediate
galanin induced
ERK activation
Hawes et al., Eur J Neurosci 2006
:
This study identified a novel physiological role for
galanin induced
ERK phosphorylation and identified ERK and protein kinase C as important signaling components in the galanin mediated modulation of neurite outgrowth
Robinet et al., FASEB J 2007
(Myocardial Reperfusion Injury) :
EPs interaction with
S-Gal triggered NO release and activation of PI3-kinase/Akt and
ERK1/2 in human coronary endothelial cells ( HCAECs ) and rat neonatal cardiomyocytes ( RCs )
Kanazawa et al., Oncogene 2007
(Carcinoma, Squamous Cell...) :
Pertussis toxin and LY294002 inhibition demonstrated that
galanin and GALR1
induce ERK1/2 activation via Galphai, not the PI3K pathway linked to the Gbetagamma subunit
Wang et al., Lab Invest 2010
(Disease Models, Animal...) :
LPS/GalN mediated phosphorylation of JNK1/2 and
ERK1/2 was differentially regulated in wild-type and PXR-null mice