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CTNNB1 — PTN
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Meng et al., Proc Natl Acad Sci U S A 2000
:
Finally, in parallel to its ability to inactivate endogenous RPTP beta/zeta,
PTN sharply
increases tyrosine phosphorylation of
beta-catenin in PTN treated cells
Pariser et al., Biochem Biophys Res Commun 2005
:
We conclude that Fyn is a downstream target of the PTN/RPTPbeta/zeta signaling pathway and suggest that
PTN coordinately
regulates tyrosine phosphorylation of
beta-catenin , beta-adducin, and Fyn through the PTN/RPTPbeta/zeta signaling pathway and that together Fyn, beta-adducin, and beta-catenin may be effectors of the previously described PTN stimulated disruption of cytoskeletal stability, increased cell plasticity, and loss of cell-cell adhesion that are characteristic of PTN stimulated cells and a feature of many human malignant cells in which mutations have established constitutive expression of the Ptn gene
Pariser et al., Biochem Biophys Res Commun 2005
:
beta-Catenin was the first downstream target of the PTN/RPTPbeta/zeta signaling pathway to be identified ; these data thus also suggest that
PTN coordinately
regulates steady state levels of tyrosine phosphorylation of the important cytoskeletal proteins beta-adducin and
beta-catenin and, through PTN stimulated tyrosine phosphorylation, beta-adducin may contribute to the disruption of cytoskeletal structure, increased plasticity, and loss of homophilic cell-cell adhesion that are the consequences of PTN stimulation of cells and a characteristic feature of different malignant cells with mutations that activate constitutive expression of the endogenous Ptn gene
Gu et al., FEBS Lett 2007
:
In this investigation, we demonstrate that
PTN plays a negative role in adipogensis and that glycogen synthase kinase 3beta ( GSK-3beta ) and
beta-catenin are
involved in the regulation of PTN mediated preadipocyte differentiation ... Knocking down the expression of
PTN using siRNA
resulted in an increase in phospho-GSK-3beta expression, and the accumulation of nuclear
beta-catenin , which are critical downstream signaling proteins for both the PTN and Wnt signaling pathways
Weng et al., J Biol Chem 2009
:
Pleiotrophin increased the tyrosine phosphorylation of beta-catenin,
promoted beta-catenin translocation into the nucleus, and activated T cell factor/lymphoid enhancer factor transcription factors