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CD4 — ITGA1

Text-mined interactions from Literome

Gendron et al., Immunology 2008 : Furthermore, we found that simultaneous activation of effector CD4 ( + ) T cells via alpha1beta1 integrin and IL-7R synergistically increases the production of RANKL and enhances their osteoclastogenic function ... Together our results identify a new function of alpha1beta1 integrin in T cells and suggest that activation of effector CD4 ( + ) T cells through alpha1beta1 integrin and IL-7R is an important regulatory pathway in T-cell dependent osteoclastogenesis
Chapman et al., J Immunol 2010 (Orthomyxoviridae Infections) : We investigated the role of VLA-1 on virus-specific CD4 ( + ) T cells during and after primary or secondary influenza infection of mice ... Airway CD49a ( + ) CD4 ( + ) cells also expressed reduced markers of apoptosis compared with CD49a ( - ) cells, and fewer memory or effector CD4 ( + ) cells could be recovered from airways of alpha ( 1 ) ( -/- ) mice, although lymphoid tissues appeared unaffected