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IL15 — STAT3

Text-mined interactions from Literome

Demoulin et al., Cytokines Cell Mol Ther 1998 : IL-2, IL-7, IL-9 and IL-15 activate STAT3 and STAT5, in contrast to IL-4, which activates STAT6
O'Brien et al., J Biol Chem 1999 : STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF-kappaB ligand and stimulation of osteoclastogenesis by gp130 utilizing cytokines or interleukin-1 but not 1,25-dihydroxyvitamin D3 or parathyroid hormone
Strengell et al., J Immunol 2003 : We also show that IL-15 activated the binding of STAT1, STAT3 , STAT4, and STAT5 to the regulatory sites of the IFN-gamma gene
Huang et al., Brain Res 2009 : Furthermore, using anti-IL-15Ralpha antibody to block IL-15 signaling completely inhibited IL-15 induced phosphorylation of STAT3 and prevented IL-15 from decreasing neurite outgrowth
Ozawa et al., Journal of ophthalmology 2011 : In innate chorioretinal inflammation, interleukin-6 family ligands induce STAT3 activation in photoreceptors, which causes UPS mediated excessive degradation of the visual substance, rhodopsin
Reinecker et al., Gastroenterology 1996 : IL-15 activates Stat3 and stimulates the proliferation of intestinal epithelial cells
Waldmann et al., Int Rev Immunol 1998 : In mast cells, IL-15 signaling involves JAK-2 and STAT-5 activation rather than the JAK-1 and JAK-3 as well as the STAT-3 and STAT-5 used by both IL-2 and IL-15 in activated T cells
Nielsen et al., Cytokine 1998 : In contrast, minimal or no activation of Stat3beta was observed, suggesting that IL-2 and IL-15 predominantly activate Stat3alpha in human CD4 ( + ) T cells