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PRL — STAT1

Text-mined interactions from Literome

Yamashita et al., J Biol Chem 1999 (Lymphoma, T-Cell) : Short term incubation ( < 60 min ) of prolactin-responsive Nb2 lymphoma cells at high density selectively blocked prolactin stimulation of p42/p44 mitogen activated protein kinases and transcription factors Stat1 and Stat3 but not prolactin activation of Stat5 or the tyrosine kinase Jak2
Mangoura et al., Int J Dev Neurosci 2000 : Our results demonstrate the ability of PRL to concurrently induce activation of PLD, a mitogenic signaling pathway in astrocytes, and prolonged stimulation of Stat1 , compatible with the increased GFAP upregulation and cell differentiation
Dogusan et al., J Neuroimmunol 2001 (Autoimmune Diseases...) : PRL also induced phosphorylation of Stat-5 in PBMC and Stat-1 in granulocytes
Gutzman et al., Oncogene 2007 (Neoplasms) : We found that PRL activation of Stat5a and Stat5b, but not Stat1 or Stat3, reduced PRL signals to AP-1, without altering estradiol induced AP-1 activity
Yang et al., J Biol Chem 2013 : STAT5A induced PRL in the conditioned medium can activate STAT5, STAT1 , and to a lesser extent STAT3 in hCMEC/D3 cells, suggesting the existence of a positive feedback loop between STAT5 and PRL that promotes angiogenesis
Wang et al., Mol Endocrinol 1997 : Multiple prolactin (PRL) receptor cytoplasmic residues and Stat1 mediate PRL signaling to the interferon regulatory factor-1 promoter
Schaber et al., Cancer Res 1998 (Breast Neoplasms) : Prolactin activates Stat1 but does not antagonize Stat1 activation and growth inhibition by type I interferons in human breast cancer cells
Jabbour et al., J Clin Endocrinol Metab 1998 : Phosphorylation of Janus kinase-2 (JAK2), STAT1 ( signal transducer and activator of transcription-1 ), and STAT5 proteins in response to PRL was investigated to establish the signaling pathway of PRL in the human endometrium