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RAF1 — RASA1
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
RASA1
→
RAF1
(increases)
Evidence: Raf significantly increased the protein levels of p120RasGAP within 24–72 hr (Figure 4B).
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WikiPathways EPO Receptor Signaling:
Complex of GRB2-RAF1-SOS1-IRS2-JAK2-IRS1-RASA1
→
MAP2K1
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Lin et al., Cell Microbiol 2003
(MAP Kinase Signaling System) :
Both tyrosine phosphatase activity and
GAP activity were responsible for SptP inhibition of Raf ( Y340D ) -induced ERK activation, but only GAP activity was
responsible for inhibition of the membrane localized forms of
Raf-1
Zhang et al., Nature 1993
:
Raf-1 ( 1-257 ) binds GTP-Ras in preference to GDP-Ras, and
inhibits Ras-GAP activity