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AGRN — RAC3
Text-mined interactions from Literome
Weston et al., J Cell Biol 2000
:
We found that
agrin causes marked muscle-specific activation of
Rac and Cdc42 in differentiated myotubes, as detected by biochemical measurements ... By indicating that
agrin dependent
activation of
Rac and Cdc42 constitutes a critical step in the signaling pathway leading to AChR clustering, these findings suggest a novel role for these Rho-GTPases : the coupling of neuronal signaling to a key step in neuromuscular synaptogenesis
Lacazette et al., J Cell Biol 2003
:
We show that neuronal Agrin by activating MuSK regulates the expression of musk via two pathways : the Agrin induced assembly of muscle derived neuregulin (NRG)-1/ErbB, the pathway thought to regulate acetylcholine receptor ( AChR ) expression at the synapse, and via a direct shunt involving
Agrin induced
activation of
Rac
Nizhynska et al., Dev Neurobiol 2007
:
Moreover,
agrin induced
activation of
Rac and Cdc42 is impaired in the presence of PI3-K inhibitors ... Its role during
agrin stimulated
Rac and Cdc42 activation suggests a critical function during cytoskeletal reorganizations, which lead to the redistribution of actin anchored AChRs
Linnoila et al., Neuron 2008
:
In cultured myotubes, Tid1 knockdown inhibited AChR clustering, as well as
agrin induced
activation of the
Rac and Rho small GTPases and tyrosine phosphorylation of the AChR, without affecting MuSK activation