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MDM2 — PI3
Text-mined interactions from Literome
Latonen et al., Cell Signal 2003
:
p53 and
MDM2 are
regulated by
PI-3-kinases on multiple levels under stress induced by UV radiation and proteasome dysfunction
Alam et al., Endocrinology 2009
:
These results indicate that FSH stimulated HIF-1 activation leading to up-regulation of targets such as vascular endothelial growth factor requires not only
PI3-kinase/AKT mediated activation of mammalian target of rapamycin as well as phosphorylation of FOXO1 and possibly
MDM2 but also a protein ( kinase ) activity that is inhibited by the classic ERK kinase inhibitor PD98059 but not ERK1/2 or 5
Singh et al., Cell Death Differ 2013
:
MDM2 requires
phosphatidylinositol (PI)3-kinase activity for enhancing Akt phosphorylation and upregulates this activity by repressing transcription of the regulatory subunit p85 of PI3-kinase