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ILK — PI3

Text-mined interactions from Literome

Wu et al., J Cell Sci 1999 : The kinase activity of ILK is regulated by both cell adhesion and growth factors in a phosphoinositide 3-kinase (PI3K) dependent manner
D'Amico et al., J Biol Chem 2000 (Breast Neoplasms) : Inhibition of the PI 3-kinase and AKT/protein kinase B, but not of the p38, ERK, or JNK signaling pathways, reduced ILK induction of cyclin D1 expression
Persad et al., J Biol Chem 2001 : However, the integrin linked kinase (ILK) has also been shown to regulate phosphorylation of serine 473 in a PI 3-kinase dependent manner
Persad et al., Cancer Metastasis Rev 2003 (Cell Transformation, Neoplastic...) : The kinase activity of ILK is stimulated upon integrin engagement, as well as by growth factors and chemokines in a PI-3Kinase dependent manner
Sawai et al., Oncogene 2006 (Disease Progression...) : Cancer cell adhesion and invasion into extracellular matrix are regulated by integrin linked kinase (ILK) activity in a phosphatidylinositol 3-kinase (PI3-K) dependent manner
Acconcia et al., Cancer Res 2006 (Breast Neoplasms...) : Estrogen prevented ERalpha-ILK binding, resulting in phosphatidylinositol 3-kinase (PI3K) dependent increase in ILK kinase activity
Liu et al., Clin Chim Acta 2007 : In this study, we investigated the role of extracellular regulating kinase 1/2 ( ERK1/2 ) and phosphatidylinositol 3-kinase (PI3-K) in the regulation of ILK expression by connective tissue growth factor (CTGF) in HK-2 cells ... Chemical inhibitors were used to assess the role of MEK/ERK1/2, PI3-K , and P38 MAPK signaling pathways in induction of ILK by CTGF
Wu et al., Am J Nephrol 2010 : LXA ( 4 ) inhibited the expression and activity of ILK and activation of Ras, ERK1/2, PI3-K and Akt in HK-2 cells stimulated by CTGF