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IARS — PI3
Text-mined interactions from Literome
Patti et al., Ann N Y Acad Sci 1999
(Diabetes Mellitus, Type 2...) :
Similarly, activation of the hexosamine pathway by infusion of glucosamine also reduces insulin stimulated phosphorylation of
IRS proteins,
activation of
PI3-kinase , and activation of glycogen synthase
Hemi et al., J Biol Chem 2002
(Insulin Resistance...) :
Similar to TNF, cycloheximide and anisomycin stimulated serine phosphorylation of IRS-1 and IRS-2, reduced their ability to interact with the insulin receptor,
inhibited the insulin induced tyrosine phosphorylation of
IRS proteins, and diminished their association with
phosphatidylinositol 3-kinase (PI3K)
Hers et al., Biochem J 2002
:
In contrast, inhibition of
PI 3-kinase led to a decrease in insulin stimulated p85 binding to
IRS-3 , but had no effect on SHP-2 binding
Kaburagi et al., Biochem Biophys Res Commun 2003
:
Overexpressed
IRS-3 as well as IRS-1
enhanced phosphoinositide (PI) 3-kinase activity in response to insulin and increased phosphorylation of protein kinase B (PKB) at S473 and phosphorylation of one of the members of the forkhead transcription factor FKHRL1 on T32 in both insulin untreated and -treated states
Folli et al., J Biol Chem 1992
:
Thus,
IRS-1 phosphorylation
plays a significant role in the activation of
PI 3-kinase in vivo by insulin
Luna et al., Diabetologia 2006
(Diabetes Mellitus, Type 2) :
In contrast,
IRS-1 dependent
phosphatidylinositol (PI) 3-kinase activity and Ser473 phosphorylation of protein kinase B were not altered by metformin therapy, whereas the responsiveness of muscle aPKC to PI-3,4,5- ( PO ( 4 ) ) ( 3 ), the lipid product of PI 3-kinase, was improved
Biswas et al., Molecular vision 2009
:
Together, these data indicate that disruption of PDGF receptor signaling compromises the pro-survival effect of insulin induced
IRS dependent
PI 3-kinase/Akt signaling in RGCs, and that the maintenance of PDGF induced PI 3-kinase/Akt signaling is critical for the survival of retinal neuronal cells
Hügl et al., J Biol Chem 1998
:
Thus, glucose and IGF-I induced beta-cell proliferation were mediated via a signaling mechanism that was facilitated by mitogen activated protein kinase but dependent on
IRS mediated induction of
PI 3'-kinase activity and downstream activation of p70 ( S6K )
Anai et al., J Biol Chem 1998
(Insulin Resistance) :
In contrast,
IRS-3 is located mainly in the plasma membrane ( PM ) fraction and
contributes to
PI 3-kinase activation in the PM fraction