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PARP1 — PCNA
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
PCNA
—
PARP1
(direct interaction, pull down)
Sekimoto et al., Mol Cell 2010*
-
IRef Biogrid Interaction:
PCNA
—
PARP1
(physical association, affinity chromatography technology)
Frouin et al., J Biol Chem 2003*
-
IRef Biogrid Interaction:
PCNA
—
PARP1
(direct interaction, pull down)
Cazzalini et al., DNA repair 2010*
-
IRef Biogrid Interaction:
PCNA
—
PARP1
(physical association, affinity chromatography technology)
Cazzalini et al., DNA repair 2010*
-
IRef Biogrid Interaction:
PCNA
—
PARP1
(physical association, affinity chromatography technology)
Lee et al., Molecular cancer 2010*
-
IRef Biogrid Interaction:
PCNA
—
PARP1
(direct interaction, pull down)
Pozo et al., Mol Cell Biol 2011*
-
IRef Hprd Interaction:
PCNA
—
PARP1
(in vivo)
Frouin et al., J Biol Chem 2003*
-
IRef Intact Interaction:
Complex of 46 proteins
(association, anti tag coimmunoprecipitation)
Abramson et al., Cell 2010
-
IRef Intact Interaction:
Complex of 306 proteins
(association, pull down)
Komarova et al., Mol Cell Proteomics 2011
-
IRef Ophid Interaction:
PCNA
—
PARP1
(aggregation, confirmational text mining)
Frouin et al., J Biol Chem 2003*
-
IRef Ophid Interaction:
PCNA
—
PARP1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Lau et al., Cancer Biol Ther 2007
(Carcinoma, Hepatocellular...) :
In the in vivo setting, YC-1 combined with cisplatin remarkably suppressed tumor growth in a HCC xenograft model, and this effect was also accompanied by YC-1 mediated downregulation of P-Stat3 ( 705 ), Bcl-xL,
Cyclin D1 and survivin, and
induction of cleaved caspase 9 and
PARP in the tumor tissues
Liu et al., BMC cancer 2010
(Brain Neoplasms...) :
Changes in several cell cycle regulators such as Cyclins D1 and E,
PCNA and Ki67, and several apoptosis related
regulators such as p53, p-JNK, p-AKT, and
PARP were determined by Western blot analysis
Zhang et al., PloS one 2012
:
It is possible that the elevated cAMP levels inhibit growth and
induce apoptosis in Hela cells through induction of p21 and cleaved
caspase-3/PARP-1 expression, and causing down-regulation of
PCNA and cell cycle arrest with accumulation of cells in the G0/G1 and G2/M fractions