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NA — POLDIP2
Text-mined interactions from Literome
Hashimoto et al., Br J Pharmacol 2001
:
However, the
effect of
N-acetylcysteine (NAC) , which acts as a precursor of glutathione ( GSH ) synthesis, on TNF-alpha induced activation of p38 MAP kinase pathway and
p38 MAP kinase mediated IL-8 production by human pulmonary vascular endothelial cells has not been determined
Park et al., Exp Mol Med 2007
:
Although 6-OHDA increased phosphorylation of
p38 was
prevented by
NAC or BAPTA, inhibition of p38 by SB203580 did not suppress ROS, Bax/Bcl-2 ratio, or caspase-3 activity increases, and only partially prevented 6-OHDA induced cell death, thus demonstrating that p38 activation is a component of a signaling pathway leading to the initiation of 6-OHDA induced cell death, which acts in parallel with an ROS-Ca ( 2+ ) -Bcl-2-caspase-3 pathway
Wu et al., Free Radic Biol Med 2009
(MAP Kinase Signaling System) :
Activation of JNK and p38MAPK was weaker in TNFalpha plus PY-treated NOS2 ( -/- ) mice and 1400W and
NAC blocked the activation of JNK and
p38MAPK in wild-type mice
Phalitakul et al., Biochem Biophys Res Commun 2012
:
NAC significantly
inhibited the PDGF-BB induced phosphorylation of
p38 and HSP27