◀ Back to MYLIP
MYLIP — TLR4
Text-mined interactions from Literome
Dai et al., Blood 2008
:
We found that
miR-146a , a negative
regulator of
Toll-like receptor ( TLR ) signaling, was decreased in freshly isolated splenic lymphocytes from estrogen treated mice compared with placebo controls
Sheedy et al., Ann Rheum Dis 2008
(Arthritis, Rheumatoid...) :
Both have multiple targets, with
miR-146 inhibiting
TLR signalling and miR-155 regulating Th1 cells and also, interestingly, positively regulating mRNA for TNFalpha
Liu et al., Proc Natl Acad Sci U S A 2009
(Inflammation) :
TLR4 induced
miR-147 expression was both MyD88- and TRIF dependent ... These data demonstrate a negative-feedback loop in which
TLR stimulation
induces miR-147 to prevent excessive inflammatory responses
Cho et al., J Cell Physiol 2010
(Calcinosis) :
Overexpression of
miR-146a induced the inhibition of IRAK1 expression and inhibited basal and TNF-alpha- and
TLR ligand
induced osteogenic differentiation
El Gazzar et al., J Biol Chem 2010
(Inflammation...) :
The process required to disrupt protein synthesis followed
Toll-like receptor 4 (TLR4) dependent induction of microRNA (miR)-221,
miR-579 , and miR-125b, which coupled with RNA binding proteins TTP, AUF1, and TIAR at the 3'-untranslated region to arrest protein synthesis
El Gazzar et al., J Leukoc Biol 2011
(Sepsis) :
Here, we used the THP-1 sepsis cell model of bacterial LPS/endotoxin tolerance to show that
TLR4 induced
miR-146a supports the feed-forward adaptive processes that silence transcription and disrupt translation of acute proinflammatory genes
Hennessy et al., J Biol Chem 2011
:
We have found that the putative miR-107 target cyclin dependent kinase 6 (CDK6) expression is increased by
TLR4 as a
result of the decrease in
miR-107
Tarassishin et al., Glia 2011
:
Astrocyte
miR-155/miR155* were
induced by cytokines and
TLR ligands with a distinct hierarchy and involved in proinflammatory cytokine gene induction by targeting suppressor of cytokine signaling 1, a negative regulator of cytokine signaling and potentially other factors
Zhao et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2012
:
Results showed that
miR-21 down-regulated
TLR4 at protein levels
Koch et al., Proc Natl Acad Sci U S A 2012
:
miR-155 is
regulated by
Toll-like receptor ( TLR ) ligands in monocyte derived cells and has been shown to be induced in macrophages during H. pylori infection
Wendlandt et al., Innate Immun 2012
:
The
role of MicroRNAs
miR-200b and miR-200c in
TLR4 signaling and NF-?B activation
Foley et al., J Leukoc Biol 2012
(Diabetes Mellitus, Type 2...) :
The decrease in
miR-107 in
response to
TLR4 may be an attempt to limit insulin resistance, a feature of obesity related inflammation
Bala et al., Journal of translational medicine 2012
(Hepatitis C, Chronic) :
Stimulation of normal monocytes with
TLR4 and TLR8 ligands or HCV core, NS3 and NS5 recombinant proteins
induced a robust increase in both
miR-155 expression and TNFa production identifying potential mechanisms for in vivo induction of miR-155 ... Our study suggests that HCV core, NS3, and NS5 proteins or
TLR4 and TLR8 ligands can
mediate increased
miR-155 and TNFa production in chronic HCV infection
Ge et al., Endocrinology 2012
(Inflammation) :
miR883b-5p , which is up-regulated by ApN
represses LBP and
Toll-like receptor-4 signaling, acting therefore as a major mediator of the antiinflammatory action of ApN
Nahid et al., J Immunol 2013
:
During bacterial infection, PGN mediated TLR2 signaling induces miR-132/-212 to downregulate IRAK4, an early component in the MyD88 dependent pathway, whereas
LPS/TLR4 induced
miR-146a downregulates downstream components of the same MyD88 dependent pathway
Lippai et al., PloS one 2013
(Alcoholism...) :
TLR4 stimulation with lipopolysaccharide in primary or immortalized mouse microglia
resulted in increased
miR-155 ... Chronic alcohol induces
miR-155 in the cerebellum in a
TLR4 dependent manner