◀ Back to MMP2

IL6 — MMP2

Text-mined interactions from Literome

Meisser et al., Mol Hum Reprod 1999 : The aim of this study was to determine the effects of tumour necrosis factor alpha (TNF), interleukin-1 alpha (IL-1alpha), macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases ( MMP ) , human chorionic gonadotrophin ( HCG ) and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro
Kossakowska et al., Blood 1999 (Lymphoma, Non-Hodgkin...) : Moreover, in human lymphoid cell lines of B- and T-cell origin ( Raji, Jurkat, and NC-37 ), IL-6 stimulated production of MMP-9 and MMP-2 but not TIMP-1
Damiens et al., Cytokine 2000 (Sarcoma) : The MMP-2 activities of the three cell lines were significantly increased in the presence of IL-1beta and IL-6 , but no modulation of MMP-2 activities was observed in the presence of OSM, LIF and GH
Shlopov et al., J Rheumatol 2001 (Osteoarthritis) : A decrease in IL-1alpha, IL-1beta, and IL-6 would reduce stimulation of MMP production, while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves
Yu et al., Oncogene 2002 (Cell Transformation, Neoplastic) : Both basal and interleukin-6 induced expression of collagenase I and stromelysin I, but not gelatinase A , were inhibited in the mutant STAT3 transfectants
Imafuku et al., Clin Chim Acta 2002 : We also found a definite effects on copper, angiotensin converting enzyme (ACE), matrix metalloproteinase (MMP)-1 , -3 and -9, tissue inhibitor of matrix metalloproteinase ( TIMP ) -1, hepatocyte growth factor (HGF), monoamine oxidase ( MAO ), vitamin B ( 12 ), ACTH and IL-6 , though the mechanisms were not clear
Phillips et al., Gut 2003 : MMP2 secretion by PSCs was significantly increased by TGF-beta1 and IL-6 , but was not affected by TNF-alpha
Hirata et al., Biol Reprod 2003 : Membrane type-1 MMP mRNA expression in the stromal cells was augmented by tumor necrosis factor alpha (TNFalpha), IL-6 , HGF, and 12-O-tetradecanoylphorbol 13-acetate
Sun et al., Connect Tissue Res 2003 (Arthritis, Rheumatoid) : Furthermore, the induction of the MMP expression and activities by interleukin-1 was suppressed by the oscillatory shear
Legendre et al., J Rheumatol 2005 (MAP Kinase Signaling System) : IL-6/sIL-6R markedly induced activation of STAT and extracellular signal related kinase ( ERK1/2 ) and the subsequent expression of the collagenases MMP-1 and MMP-13 as well as MMP-3, an aggrecan degrading enzyme and activator of pro-MMP
Previti et al., Journal of neuroinflammation 2006 : However, later stage pathological consequences of Abeta treatment associated with inflammation and cell degeneration including increased levels of IL-6 , activation of MMP-2 , and loss of HCSM alpha actin were significantly diminished by dexamethasone but not by indomethacin or ibuprofen ... Our results suggest that although dexamethasone has no appreciable consequence on HCSM cell surface fibrillar Abeta accumulation it effectively reduces the subsequent pathologic responses including elevated levels of IL-6 , MMP-2 activation , and depletion of HCSM alpha actin
Ahmed et al., Proc Natl Acad Sci U S A 2008 (Arthritis, Rheumatoid...) : Gelatin zymography results showed EGCG inhibits IL-6/soluble IL-6R induced matrix metalloproteinase-2 activity in RA synovial fibroblasts and in joint homogenates, possibly via up-regulation of sgp130 synthesis
Li et al., J Cell Biochem 2010 (MAP Kinase Signaling System) : Although it is known that interleukin (IL)-6 is a key proinflamatory cytokine, it remains unclear how IL-6 regulates MMP expression by mononuclear phagocytes ... Furthermore, it remains undetermined how IL-6 in combination with hyperglycemia affects MMP expression
Li et al., Oncol Rep 2010 (Brain Neoplasms...) : An advanced level of STAT3 activity, and increased expression and secretion of MMP-2 , induced by IL-6 in U87 MG cells were observed
Teixeira-Clerc et al., Hepatology 2010 (Disease Models, Animal...) : Impaired liver regeneration was consecutive to an interleukin-6 (IL-6) mediated decrease in matrix metalloproteinase 2 (MMP-2) activity
Okumura et al., J Cardiovasc Electrophysiol 2011 (Atrial Fibrillation...) : Overall, hs-CRP, IL-6 , ANP, and BNP levels decreased, and MMP-2 , TIMP-2, and ICTP levels increased 2 months after ablation
Hoffmann et al., Biochem Pharmacol 2011 (Adenocarcinoma...) : Proinflammatory IL-6 and PGHS-2 as well as proangiogenic IL-8 and VEGF were induced by IL-1, whereas the secretion of invasion promoting MMP-2 remained unaffected
Clérigues et al., Biochem Pharmacol 2012 (Osteitis...) : HO-1 induction significantly reduced the expression of matrix metalloproteinase (MMP)-1, MMP-2 and MMP-3, and the production of pro-inflammatory cytokines such as tumor necrosis factor-a and IL-6 whereas IL-10 levels increased
Kesanakurti et al., Oncogene 2013 (Cell Transformation, Neoplastic...) : Our data indicate the possible role of MMP-2/a5ß1 interaction in the regulation of a5ß1 mediated IL-6/Stat3 signaling activation and signifies the therapeutic potential of blocking MMP-2/a5ß1 interaction in glioma treatment
Mann et al., Ann Otol Rhinol Laryngol 1995 (Carcinoma, Squamous Cell...) : Supernatants of HNSCC cell lines SCC-25 and FADU stimulated with interleukin (IL)-1 alpha and IL-1 beta demonstrated modest induction of 92 kd GL production by zymogram analysis when compared with controls ; IL-2, IL-6 , and interferon-gamma had no consistent effect on MMP production
Richards et al., J Immunol 1993 (Neoplasms) : The results suggest that OM as well as IL-6 and LIF, other cytokines acting through similar receptor pathways, may act to inhibit net MMP activity by specifically up-regulating TIMP-1 expression
Salamonsen et al., Hum Reprod 1996 : Progesterone withdrawal from stromal cell cultures ( for the final 4 days of a 10 day culture ) increased the release of all four enzymes : all but MMP-2 were also stimulated by interleukin-1 or tumour necrosis factor alpha added to short-term stromal cultures
Kusano et al., Endocrinology 1998 (Bone Resorption) : IL-6 with sIL-6R also induced expression of MMP-13 and MMP-2 mRNAs on day 2, but the expression was rather transient