Gene interactions and pathways from curated databases and text-mining

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HIPK3 — JUN

Text-mined interactions from Literome

Lan et al., Mol Cell Biol 2007 : HIPK3 enhanced SF-1 activity, and c-Jun was required for the functional interaction of HIPK3 with SF-1 ... Thus, we have defined HIPK3 mediated JNK activity and c-Jun phosphorylation as important events that increase SF-1 activity for CYP11A1 transcription in response to cAMP
Lan et al., J Biol Chem 2012 : It up-regulates the expression of the steroidogenic Cyp11a1 gene in the adrenal in a pathway stimulated by cAMP through HIPK3 mediated JNK/c-Jun phosphorylation