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GIF — IL12B

Text-mined interactions from Literome

Shrayer et al., Clin Exp Metastasis 1999 (Lung Neoplasms...) : Interleukin (IL)-12 can activate cytotoxic lymphocytes, stimulate natural killer cell activity, induce the production of INF-gamma and inhibit the development of various experimental tumors
Tsai et al., Cytokine 2005 (Periodontal Diseases) : IL-12 is an inducer of INF-r production
Koch et al., Clin Immunol 2007 (Asthma) : Furthermore, the authors have studied the IL-12 induced expression of the T ( H ) 1-associated cytokine INF-gamma and the IL-4 induced expression of the T ( H ) 2-specific cytokine IL-5 in the presence of LPS using ELISA and compared nine atopic asthmatic subjects and eleven nonatopic normal volunteers ... Interestingly, LPS increased the IL-12 induced INF-gamma release in a concentration dependent manner in T-lymphocytes of normals but this could not be found in T cells of asthmatics, indicating an impaired T ( H ) 1 response to bacterial endotoxin LPS in asthma