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GSK3B — WNT3A

Pathways - manually collected, often from reviews:

• NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2) → Axin1/GSK3 complex (AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Zeng et al., Nature 2005, Bilic et al., Science 2007, Zeng et al., Development 2008
  Evidence: assay, physical interaction
• NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Zeng et al., Nature 2005, Bilic et al., Science 2007, Zeng et al., Development 2008
  Evidence: assay, physical interaction
• NCI Pathway Database Canonical Wnt signaling pathway: Axin1/GSK3 complex (AXIN1-GSK3B_GSK3A) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Zeng et al., Nature 2005, Bilic et al., Science 2007, Zeng et al., Development 2008
  Evidence: assay, physical interaction
• NCI Pathway Database Canonical Wnt signaling pathway: beta catenin (CTNNB1) → WNT3A/LRP6/FZD5/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: APC (APC) → WNT3A/LRP6/FZD5/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1) → WNT3A/LRP6/FZD5 complex (WNT3A-LRP6-FZD5) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1) → WNT3A/LRP6/FZD5/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5 complex (WNT3A-LRP6-FZD5) → WNT3A/LRP6/FZD5/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Degradation of beta catenin: CK1 epsilon-CK1 delta-CK1 alpha (CSNK1E/CSNK1A1/CSNK1D) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, activates)
  Kishida et al., Oncogene 1999, Kodama et al., J Biol Chem 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Orford et al., J Biol Chem 1997, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2) → Axin1/GSK3 complex (AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Piao et al., PloS one 2008, Yum et al., Biochem Biophys Res Commun 2009
  Evidence: assay, physical interaction
• NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Piao et al., PloS one 2008, Yum et al., Biochem Biophys Res Commun 2009
  Evidence: assay, physical interaction
• NCI Pathway Database Canonical Wnt signaling pathway: Axin1/GSK3 complex (AXIN1-GSK3B_GSK3A) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Piao et al., PloS one 2008, Yum et al., Biochem Biophys Res Commun 2009
  Evidence: assay, physical interaction
• NCI Pathway Database Canonical Wnt signaling pathway: beta catenin (CTNNB1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: beta catenin (CTNNB1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: APC (APC) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: APC (APC) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5/DVL/Axin1/GSK3/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: CK1 gamma (CSNK1G1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, activates)
  Davidson et al., Nature 2005, Zeng et al., Nature 2005, Zeng et al., Development 2008
  Evidence: assay, physical interaction
• NCI Pathway Database Canonical Wnt signaling pathway: CK1 gamma (CSNK1G1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, activates)
  Zeng et al., Nature 2005, Piao et al., PloS one 2008, Yum et al., Biochem Biophys Res Commun 2009
  Evidence: assay, physical interaction
• NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2) → Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: APC (APC) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: beta catenin (CTNNB1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• Reactome Reaction: WNT3A → GSK3B (reaction) Mao et al., Mol Cell 2001, Tamai et al., Mol Cell 2004, He et al., Development 2004, Zeng et al., Nature 2005, Schwarz-Romond et al., Nature structural & molecular biology 2007, Bilic et al., Science 2007, Zeng et al., Development 2008, MacDonald et al., J Biol Chem 2008
• Reactome Reaction: WNT3A → GSK3B (indirect_complex) Mao et al., Mol Cell 2001, Tamai et al., Mol Cell 2004, He et al., Development 2004, Davidson et al., Nature 2005, Zeng et al., Nature 2005, Yamamoto et al., Dev Cell 2006, Schwarz-Romond et al., Nature structural & molecular biology 2007, Bilic et al., Science 2007, Zeng et al., Development 2008, MacDonald et al., J Biol Chem 2008, Yamamoto et al., Dev Cell 2008

Text-mined interactions from Literome

Almeida et al., J Biol Chem 2005 : Wnt3a induced phosphorylation of GSK-3beta and downstream activation of beta-catenin mediated transcription required ERK, PI3K, and Akt signaling
Shi et al., Mol Cell Biol 2006 : Reduction of GCKR expression inhibits Wnt3a induced phosphorylation of GSK3beta at serine 9 and decreases the accumulation of cytosolic beta-catenin
Soda et al., Cell Signal 2008 : Therefore, we asked if TPO and Wnt3a can both inhibit GSK-3beta in megakaryocytic cells, and if they can act synergistically to promote cell growth
Sonderegger et al., Endocrinology 2010 : Western blot analyses revealed that the recombinant Wnt ligand Wnt-3A increased phosphorylation of AKT and the downstream kinase glycogen synthase kinase (GSK)-3beta as well as accumulation of activated, nuclear beta-catenin