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CDKN1A — FGF7
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
CDKN1A
→
FGF7
(increases)
Johnson et al., Oncogene 1998*
Evidence: FGF2 induced increase in p21/waf1 levels in MCF-7 cells. Whereas, in T47D cells under the same condition showed no detectable induction of p21 by FGF. FGF7 also increased the levels of p21, but to a lesser extent.
Text-mined interactions from Literome
Kivinen et al., Cell Growth Differ 1999
:
In contrast,
FGF-2 regulation of
p21 is largely independent of MEK and Ras
Bellosta et al., J Bone Miner Res 2003
:
We studied the expression of several cell cycle regulatory molecules in response to fibroblast growth factor, and found that
fibroblast growth factor strongly
upregulates the expression of
p21 ( WAF1/CIP1 ), a CDK inhibitor that has also been implicated in the regulation of apoptosis and cell differentiation
Johnson et al., Oncogene 1998
(Breast Neoplasms...) :
FGF signaling
activates STAT1 and
p21 and inhibits the estrogen response and proliferation of MCF-7 cells