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CREB5 — NGF
Text-mined interactions from Literome
Zhang et al., Neurobiol Aging 1999
(Alzheimer Disease...) :
Oxidative stress differentially modulates phosphorylation of ERK, p38 and
CREB induced by
NGF or EGF in PC12 cells
Mandolesi et al., FEBS Lett 2002
:
NGF dependent and tissue-specific transcription of vgf is
regulated by a
CREB-p300 and bHLH factor interaction
Bedogni et al., J Biol Chem 2003
:
We found that ROS are necessary for
NGF dependent phosphorylation of
CREB , an event directly correlated with CREB activity, whereas hydrogen peroxide induces a robust CREB phosphorylation
Chakrabarti et al., Mol Cell Biol 2005
:
Furthermore, elevated Kalirin expression resulted in catalytic activation of TrkA, as demonstrated by in vitro kinase assays and increased
NGF stimulated cellular activation of Rac, Mek, and
CREB
McCauslin et al., J Biol Chem 2006
(Glioma) :
Here we have further defined the function of C/EBPdelta and identified a
role for cAMP response element binding protein (
CREB ) in
NGF transcription
Sun et al., Genes Cells 2006
:
Here we show that
NGF signaling
induces sustained activation of M-Ras and subsequent sustained activation of ERK pathway and the transcription factor
CREB leading to PC12 cell differentiation
Washio et al., Exp Cell Res 2009
:
Western blot analysis revealed that HA suppressed
NGF induced phosphorylation of p38 MAPK, ERKs, and transcriptional factor
CREB in PC12 cells
Bonni et al., Mol Cell Neurosci 1995
:
Whereas CREB can mediate calcium- or cyclic AMP induced c-fos transcription independently of other promoter bound transcription factors,
CREB mediates
NGF induction of c-fos transcription via a novel mechanism that appears to require a cooperative interaction with another transcription factor, the serum response factor
Monaco et al., Oncogene 1997
:
ICER induction correlates with a
NGF mediated phosphorylation of
CREB
Ahn et al., Mol Cell Biol 1998
:
Lastly,
A-CREB attenuated
NGF induction of morphological differentiation in PC12 cells
Xing et al., Mol Cell Biol 1998
:
Inhibition of either the ERK/RSK or the p38/MAPKAP kinase 2 pathway only partially blocked
NGF induced
CREB Ser-133 phosphorylation, suggesting that either pathway alone is sufficient for coupling the NGF signal to CREB activation ... However, inhibition of both the ERK/RSK and the p38/MAPKAP kinase 2 pathways completely abolished
NGF induced
CREB Ser-133 phosphorylation