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CDKN1A — MMP1
Text-mined interactions from Literome
Perlman et al., J Immunol 2003
(Arthritis, Rheumatoid) :
IL-6 and
matrix metalloproteinase-1 are
regulated by the cyclin dependent kinase inhibitor
p21 in synovial fibroblasts
Bower et al., Oncogene 2004
(Carcinoma, Hepatocellular...) :
We show here that overexpression of
p21SNFT in HepG2 cells
leads to repression of
matrix metalloproteinase-1 by 70-80 %
Garg et al., Cancer Res 2010
(Colitis...) :
Despite being a mediator of proinflammatory responses in colitis,
MMP-9 plays a protective role and acts as a tumor suppressor in CAC by modulating Notch-1 activation, thereby
resulting in activation of
p21 ( WAF1/Cip1 ) and suppression of beta-catenin
Chan et al., International journal of molecular sciences 2011
:
In the current study, pretreatment with nitric oxide ( NO ) scavengers inhibited PDT induced mitochondrial
membrane potential ( MMP ) changes,
activation of caspase-9, caspase-3,
p21 activated protein kinase 2 (PAK2) and c-Jun N-terminal kinase (JNK), and gene expression of p53 and p21 involved in apoptotic signaling