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CDKN1A — FAS
Text-mined interactions from Literome
Menendez et al., Int J Oncol 2004
(Breast Neoplasms) :
In SK-Br3 cells, cerulenin induced inhibition of
FAS activity
resulted in down-regulation of p53, and up-regulation of cyclin dependent kinase inhibitor (CDKi)
p21WAF1/CIP1
Menendez et al., Oncogene 2004
(Adenocarcinoma...) :
Moreover, depletion of
FAS by RNAi also
caused loss of ERalpha expression, downregulation of PR, and accumulation of
p21WAF1/CIP1 and p27Kip1 in E2-stimulated Ishikawa cells
Zhang et al., J Biol Chem 2008
:
Overexpression of
p21 suppressed MDM2, elevated p53 levels, and
enhanced CD95 , BAX, NOXA, and PUMA expression ; knockdown of BAX/NOXA/PUMA reduced CDK inhibitor stimulated cell killing
Sharma et al., Am J Obstet Gynecol 2009
(Ovarian Neoplasms) :
OM-3FAs increased the level of TGF-beta1, Smad-3, and
p21 protein in ovarian cancer cells known to be more sensitive to their inhibitory effect