Wu-Wong et al., Curr Opin Investig Drugs 2006
(Cardiovascular Diseases...) :
The effect of VDR activators on the modulation of renin expression and vascular functions may be factors that contribute to reduced mortality and morbidity risk in VDR-activator treated CKD patients
Fryer et al., Nephron. Physiology 2007
:
Vitamin D receptor activators ( VDRAs ) may suppress renin expression and VDR mediated renin inhibitors may offer a novel mechanism to control the RAS
Nakane et al., Nephron. Physiology 2007
:
Mechanistic analysis of VDR mediated renin suppression ... The vitamin D receptor (VDR) is involved in the regulation of renin expression and vitamin D analogs down-regulated renin mRNA expression in As4.1 cells ... Treatment of the cells with siRNA against nuclear receptor co-repressor ( NCOR1 ) eliminated VDR mediated renin suppression ... These results suggest that VDR mediated renin suppression likely acts through a transcriptional regulatory complex including CREB1, NCOR1 and VDR that binds to the CRE-like domain in the renin enhancer region
Chandel et al., Am J Physiol Cell Physiol 2012
:
We evaluated the role of vitamin D receptor (VDR) and the activation of the renin-angiotensin system (RAS) in morphine induced T cell loss