Kasai et al., Genes Cells 2004
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We found that the G12 family of heterotrimeric G proteins and the small GTPase RhoA are involved in Shh/Smo mediated cellular responses, including stimulation of target gene promoter and inhibition of neurite outgrowth of neuroblastoma cells
Chinchilla et al., Cell cycle (Georgetown, Tex.) 2010
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Consistent with the required cytoskeletal re-arrangement for tubulogenesis, Shh , Ihh and Dhh all stimulated the small GTPase RhoA and the formation of actin stress fibers
Polizio et al., J Biol Chem 2011
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We found that Shh acutely stimulates the small Rho GTPases Rac1 and RhoA via SMO through a G ( i ) protein- and PI3K dependent mechanism, and that these are required for cell migration