Gene interactions and pathways from curated databases and text-mining

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CFL2 — RHOA

Text-mined interactions from Literome

Huang et al., J Cell Sci 2011 : Slit-2 repels the migration of olfactory ensheathing cells by triggering Ca2+ dependent cofilin activation and RhoA inhibition
Xie et al., J Mol Neurosci 2012 (Brain Neoplasms...) : Moreover, the significant increases in RhoA activity, myosin light chain ( MLC ) and cofilin phosphorylation by EMAP II administration were observed, MLC and cofilin phosphorylation were partly inhibited by C3 exoenzyme or Y27632 pretreatment
Bhoopathi et al., Cell Signal 2011 (Medulloblastoma...) : The reduced phosphorylation level of cofilin , which is indicative of receding Rho function, in turn led to inhibition of active Rho A ... Transfection with SPARC siRNA reversed Src mediated disruption of the cytoskeleton organization as well as dephosphorylation of cofilin and activation of Rho A