Gene interactions and pathways from curated databases and text-mining

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LTB — PTGS2

Text-mined interactions from Literome

Sugaya et al., Jpn J Pharmacol 2000 (Alzheimer Disease) : However, such drugs may also trigger unwanted effects ; for example, the COX-2 inhibitors, which reduce the production of one type of eicosanoids, the prostaglandins, may increase the production of other eicosanoids ; i.e., the leukotriene B4 (LTB4) , which is one of the most potent endogenous chemotactic/inflammatory factors
Vardar et al., J Periodontol 2005 (Disease Models, Animal...) : The present study was planned to evaluate the individual and combined effects of selective cyclooxygenase-2 (COX-2) inhibitor, celecoxib, and omega-3 fatty acid on the gingival tissue levels of prostaglandin E2 ( PGE2 ), prostaglandin F2alpha ( PGF2alpha ), leukotriene B4 (LTB4) , and platelet activating factor (PAF) in endotoxin induced periodontitis in rats