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DDT — PTGS2

Text-mined interactions from Literome

Han et al., Toxicol Appl Pharmacol 2008 : o, p'-DDT induces cyclooxygenase-2 gene expression in murine macrophages : Role of AP-1 and CRE promoter elements and PI3-kinase/Akt/MAPK signaling pathways ... Furthermore, o, p'-DDT dose-dependently increased the levels of COX-2 protein and mRNA ... These results demonstrate that o, p'-DDT induced COX-2 expression via AP-1 and CRE activation through the PI3-K/Akt/ERK, JNK, and p38 MAP kinase pathways
Han et al., Toxicol Lett 2010 (Breast Neoplasms) : In addition, o, p'-DDT increased COX-2 protein levels markedly, increased COX-2 mRNA expression and promoter activity, enhanced the production of prostaglandin E ( 2 ) ( PGE ( 2 ) ), induced cyclic AMP response element ( CRE ) activation, and cAMP levels and binding of CREB
Xin et al., Mol Cancer Res 2010 (Colorectal Neoplasms) : The MIF homologue D-dopachrome tautomerase promotes COX-2 expression through ß-catenin dependent and -independent mechanisms ... D-DT dependent COX-2 transcription is mediated in part by ß-catenin protein stabilization and subsequent transcription