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CFTR — PTGS2

Text-mined interactions from Literome

Chen et al., J Cell Physiol 2012 (Cystic Fibrosis...) : More importantly, overexpression of wild-type CFTR significantly suppressed COX-2 expression in CFBE41o- cells, and wild-type CFTR protein expression was significantly increased when 16HBE14o -- cells were challenged with LPS as well as PGE ( 2 ), indicating possible involvement of CFTR in negative regulation of COX-2/PGE ( 2 )
Chen et al., Hum Reprod 2012 (Cryptorchidism...) : Our previous study has demonstrated that CFTR negatively regulates NF-?B/COX-2/PGE ( 2 ) in bronchial epithelial cells ... Inhibition or knockdown of CFTR led to increased COX-2 but decreased ZO-1 and occludin expression in Sertoli cells, which could be mimicked by PGE ( 2 ), but reversed by NF-?B or COX-2 inhibitor, suggesting that the regulation of TJs by CFTR is mediated by a NF-?B/COX-2/PGE ( 2 ) pathway