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HGF — PRKCA

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: PRKCA → HGF (increases, HGF Activity)
  Evidence: Modified assertion
• OpenBEL Selventa BEL large corpus: PRKCA → HGF (decreases) Ma et al., Br J Cancer 2007*
  Evidence: In c-MET-overexpressing SCLC cell line NCI-H69, hepatocyte growth factor (HGF) dramatically induced c-MET phosphorylation at phosphoepitopes pY1230/1234/1235 (catalytic tyrosine kinase), pY1003 (juxtamembrane), and also of paxillin at pY31 (CRKL-binding site). We utilised a global proteomics phosphoantibody array approach to identify further c-MET/HGF signal transduction intermediates in SCLC. Strong HGF induction of specific phosphorylation sites in phosphoproteins involved in c-MET/HGF signal ...

Text-mined interactions from Literome

Kermorgant et al., Am J Physiol Gastrointest Liver Physiol 2001 (Colonic Neoplasms) : HGF also stimulated expression and tyrosine phosphorylation of c-Met and Gab-1 as well as protein kinase C (PKC)-alpha expression
Syed et al., Toxicol Appl Pharmacol 2008 (Breast Neoplasms...) : Inhibition of HGF mediated membrane translocation of PKCalpha as well as decreased phosphorylation of STAT3 was further observed in delphinidin treated cells