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NOTCH3 — PSEN2
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Ye et al., Nature 1999
(Alzheimer Disease) :
They also link the
role of
presenilin in
Notch signalling to its effect on amyloid production in Alzheimer 's disease
Saxena et al., J Biol Chem 2001
:
Despite a high degree of structural homology and the
presenilin dependent activity of truncated
Notch proteins, the extent that this reflects functional redundancy is unknown
Wang et al., J Biol Chem 2004
:
The intramembranous cleavage of Alzheimer beta-amyloid precursor protein and the signaling receptor
Notch is
mediated by the
presenilin ( PS, PS1/PS2 ) -gamma-secretase complex, the components of which also include nicastrin, APH-1, and PEN-2
Wacker et al., EMBO J 2011
:
Ligand binding induces
presenilin dependent cleavage of the receptor and a subsequent nuclear translocation of the
Notch intracellular domain ( NICD )
Singh et al., Dev Cell 2012
:
Hibris, a Drosophila nephrin homolog, is required for
presenilin mediated
Notch and APP-like cleavages
Levitan et al., Development 1998
:
We discuss potential parallels for the
role of
SEL-12/presenilin in facilitating
LIN-12/Notch activity and in amyloid precursor protein (APP) processing