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NCL — NPM1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Aurora B signaling:
NSUN2 (NSUN2)
→
NSUN2/NPM1/Nucleolin complex (NSUN2-NPM1-NCL)
(modification, collaborate)
Sakita-Suto et al., Mol Biol Cell 2007*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Aurora B signaling:
Nucleolin (NCL)
→
NSUN2/NPM1/Nucleolin complex (NSUN2-NPM1-NCL)
(modification, collaborate)
Sakita-Suto et al., Mol Biol Cell 2007*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Aurora B signaling:
Nucleolin (NCL)
→
NPM1 (NPM1)
(modification, collaborate)
Sakita-Suto et al., Mol Biol Cell 2007*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Aurora B signaling:
Aurora B (AURKB)
→
NSUN2/NPM1/Nucleolin complex (NSUN2-NPM1-NCL)
(modification, activates)
Sakita-Suto et al., Mol Biol Cell 2007*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Aurora B signaling:
NSUN2/NPM1/Nucleolin complex (NSUN2-NPM1-NCL)
→
NPM1 (NPM1)
(modification, collaborate)
Sakita-Suto et al., Mol Biol Cell 2007*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Aurora B signaling:
NSUN2 (NSUN2)
→
NSUN2/NPM1/Nucleolin complex (NSUN2-NPM1-NCL)
(modification, collaborate)
Sakita-Suto et al., Mol Biol Cell 2007*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Aurora B signaling:
Nucleolin (NCL)
→
NSUN2/NPM1/Nucleolin complex (NSUN2-NPM1-NCL)
(modification, collaborate)
Sakita-Suto et al., Mol Biol Cell 2007*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Aurora B signaling:
Nucleolin (NCL)
→
NPM1 (NPM1)
(modification, collaborate)
Sakita-Suto et al., Mol Biol Cell 2007*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Aurora B signaling:
Aurora B (AURKB)
→
NSUN2/NPM1/Nucleolin complex (NSUN2-NPM1-NCL)
(modification, activates)
Sakita-Suto et al., Mol Biol Cell 2007*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Aurora B signaling:
NSUN2/NPM1/Nucleolin complex (NSUN2-NPM1-NCL)
→
NPM1 (NPM1)
(modification, collaborate)
Sakita-Suto et al., Mol Biol Cell 2007*
Evidence: mutant phenotype, assay, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
Complex of 46 proteins
Hayano et al., J Biol Chem 2003
-
IRef Biogrid Interaction:
NCL
—
NPM1
(colocalization, biochemical)
Havugimana et al., Cell 2012
-
IRef Biogrid Interaction:
NCL
—
NPM1
(colocalization, biochemical)
Okuwaki et al., Nucleic Acids Res 2012*
-
IRef Biogrid Interaction:
NCL
—
NPM1
(physical association, affinity chromatography technology)
Yu et al., Mol Cell Biol 2006*
-
IRef Biogrid Interaction:
NCL
—
NPM1
(physical association, affinity chromatography technology)
Li et al., Eur J Biochem 1996*
-
IRef Biogrid Interaction:
NCL
—
NPM1
(direct interaction, pull down)
Li et al., Eur J Biochem 1996*
-
IRef Biogrid Interaction:
NCL
—
NPM1
(physical association, affinity chromatography technology)
Park et al., Protein J 2010
-
MIPS CORUM TLE1 corepressor complex (MASH1 promoter-corepressor complex):
TLE1 corepressor complex (MASH1 promoter-corepressor complex) complex (ACTB-HSPA4-MYH10-NCL-NONO-NPM1-PARP1-RAD50-TLE1-TOP2B)
Ju et al., Cell 2004
-
MIPS CORUM Nop56p-associated pre-rRNA complex:
Nop56p-associated pre-rRNA complex complex (ACTA2-ACTG2-BRIX1-DDX21-DHX9-EBNA1BP2-EEF1A1-EEF2-FBL-GNL3-H1FX-HIST1H1D-HIST1H2BM-HNRNPA1-HNRNPM-HNRNPU-IGF2BP1-ILF2-ILF3-LUC7L2-LYAR-MYBBP1A-NAP1L1-NCL-NHP2L1-NOP58-NOP56-NOLC1-NPM1-PWP1-RBM28-RPL10-RPL10A-RPL11-RPL12-RPL13-RPL13A-RPL14-RPL15-RPL17-RPL18-RPL18A-RPL19-RPL21-RPL22-RPL23-RPL23A-RPL24-RPL26-RPL27-RPL27A-RPL28-RPL29-RPL3-RPL30-RPL31-RPL32-RPL35-RPL35A-RPL36-RPL36A-RPL37A-RPL39-RPL4-RPL5-RPL6-RPL7-RPL7A-RPL8-RPL9-RPLP0-RPLP1-RPLP2-RPS11-RPS12-RPS13-RPS14-RPS15-RPS15A-RPS16-RPS17-RPS18-RPS2-RPS23-RPS24-RPS29-RPS3A-RPS6-RPS7-RPS8-RPS9-RSL1D1-SCYL2-SLC25A5-SRP14-SRPK1-TCOF1-TOP1-TUBA1A-TUBB1-TUFM-U2AF1-U2AF2-YBX1)
Hayano et al., J Biol Chem 2003
-
MIPS CORUM TLE1 corepressor complex (MASH1 promoter-corepressor complex):
TLE1 corepressor complex (MASH1 promoter-corepressor complex) complex (HSPA4-NCL-NONO-NPM1-PARP1-RAD50-TLE1-TOP2B)
Ju et al., Cell 2004
-
IRef Corum Interaction:
Complex of NPM1-PARP1-NCL-HSPA4-TOP2B-TLE1-NONO-RAD50
(association, molecular sieving)
Ju et al., Cell 2004
-
IRef Corum Interaction:
Complex of 209 proteins
(association, anti tag coimmunoprecipitation)
Hayano et al., J Biol Chem 2003
-
IRef Corum Interaction:
Complex of 31 proteins
(association, anti tag coimmunoprecipitation)
Ju et al., Cell 2004
-
IRef Hprd Interaction:
Complex of 2739 proteins
(in vivo)
Czubaty et al., Biochim Biophys Acta 2005
-
IRef Hprd Interaction:
NCL
—
NPM1
(two hybrid)
Liu et al., Cancer Lett 1999*, Li et al., Eur J Biochem 1996*
-
IRef Hprd Interaction:
NCL
—
NPM1
(in vivo)
Liu et al., Cancer Lett 1999*, Li et al., Eur J Biochem 1996*
-
IRef Hprd Interaction:
NCL
—
NPM1
(in vitro)
Liu et al., Cancer Lett 1999*, Li et al., Eur J Biochem 1996*
-
IRef Intact Interaction:
Complex of 28 proteins
(association, pull down)
Czubaty et al., Biochim Biophys Acta 2005
-
IRef Intact Interaction:
Complex of 28 proteins
(association, pull down)
Czubaty et al., Biochim Biophys Acta 2005
-
IRef Intact Interaction:
Complex of 50 proteins
(association, anti tag coimmunoprecipitation)
Li et al., Mol Cell Biol 2003
-
IRef Intact Interaction:
Complex of 228 proteins
(association, pull down)
Blagoev et al., Nat Biotechnol 2003
-
IRef Intact Interaction:
Complex of 39 proteins
(association, anti tag coimmunoprecipitation)
Liu et al., Nature 2012
-
IRef Intact Interaction:
Complex of 168 proteins
(association, cross-linking study)
Byron et al., Proteomics 2012
-
IRef Intact Interaction:
Complex of 400 proteins
(association, cross-linking study)
Humphries et al., Science signaling 2009
-
IRef Intact Interaction:
Complex of 62 proteins
(association, tandem affinity purification)
Vandamme et al., Mol Cell Proteomics 2011
-
IRef Intact Interaction:
Complex of 72 proteins
(physical association, molecular sieving)
Bernhard et al., J Am Soc Mass Spectrom 2004
-
IRef Intact Interaction:
Complex of 114 proteins
(association, anti tag coimmunoprecipitation)
Höck et al., EMBO Rep 2007
-
IRef Ophid Interaction:
NPM1
—
NCL
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Yang et al., Nucleic Acids Res 2002
:
UV radiation
induces the protein expression levels and RNA binding activity of
NPM while
nucleolin RNA binding activity increases after UV or ionizing radiation exposure
Inder et al., J Biol Chem 2009
(MAP Kinase Signaling System) :
NPM and
nucleolin both stabilize K-Ras levels on the plasma membrane, but
NPM concurrently
increases the clustered fraction of GTP-K-Ras