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MYLIP — SMAD3
Text-mined interactions from Literome
Qin et al., J Am Soc Nephrol 2011
(Fibrosis...) :
In cultured fibroblasts and tubular epithelial cells,
Smad3 mediated TGF-ß ( 1 ) -induced downregulation of
miR-29 by binding to the promoter of miR-29
Wang et al., J Cell Mol Med 2012
(Disease Models, Animal...) :
TGF-ß ( a pathological mediator of fibrotic disease ) increased miR-24 expression, overexpression of
miR-24 reduced TGF-ß secretion and
Smad2/3 phosphorylation in CFs
Xiao et al., Mol Ther 2012
(Disease Models, Animal...) :
Interestingly, overexpression of
miR-29 could in turn negatively
regulated TGF-ß and connective tissue growth factor (CTGF) expression and
Smad3 signaling ... In conclusion,
miR-29 is negatively
regulated by
TGF-ß/Smad3 and has a therapeutic potential for pulmonary fibrosis
Noetel et al., Frontiers in physiology 2012
:
miR-21 is transcriptionally upregulated in
response to
Smad-3 rather than Smad-2 activation after TGF-ß stimulation
Vaporidi et al., Am J Physiol Lung Cell Mol Physiol 2012
(Disease Models, Animal...) :
In TGF-ß signaling network,
SMAD-4 ,
regulated by
miR-146 , appeared as a central node
Dey et al., Genes Dev 2012
:
Inhibiting
miR-26a in the tibialis anterior muscles through the injection of adeno associated virus expressing a Tough-Decoy targeting miR-26a
prevents Smad down-regulation and delays regeneration
Chung et al., Mol Ther 2013
(Fibrosis...) :
In conclusion, Smad7 protects kidneys from fibrosis by regulating
TGF-ß/Smad3 mediated renal expression of
miR-21 , miR-192, and miR-29b