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MYC — SKP2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MYC → SKP2 (directlyIncreases, SKP2 Activity) von der Lehr et al., Mol Cell 2003*
  Evidence: Further, Myc-induced transcription was shown to be Skp2 dependent, suggestinginterdependence between c-Myc and Skp2 in activation of transcription. Moreover,Myc-dependent association of Skp2, ubiquitylated proteins, and subunits of theproteasome to a c-Myc target promoter was demonstrated in vivo. The resultssuggest that Skp2 is a transcriptional cofactor for c-Myc and indicates a closerelationship between transcription activation and transcription factorubiquitination.
• OpenBEL Selventa BEL large corpus: MYC → Complex of CUL1-RBX1-SKP1-SKP2 (increases, CUL1/RBX1/SKP1/SKP2 Activity)
  
  Evidence: It has been reported that during the G1 to S transition of the cell cycle, Skp2 regulates the ubiquitinylation and stability of the transcription factor c-Myc, an oncoprotein that plays a major role in oncogenesis Skp2 enhances c-Myc-induced S phase transition and activates c-Myc transcriptional activity.
• OpenBEL Selventa BEL large corpus: MYC → Complex of MYC-SKP2 (increases, MYC/SKP2 Activity)
  Evidence: Inhibition of either KPC1 or KPC2 by RNA interference or with dominant-negative mutants delays p27 degradation at the G0 G1 transition . These results indicate that the degradation of p27 is regulated by two distinct mechanisms: translocation-coupled cytoplasmic ubiquitylation by KPC at the G0 G1 transition and nuclear ubiquitylation by SKP2 during S and G2 phases (see Supplementary information S2 (figure)). Given that, in a subset of breast cancers (32 out of 84 samples)45, p27 levels were low ...
• NCI Pathway Database C-MYC pathway: SKP2 (SKP2) → MYC/Max complex (MYC-MAX) (modification, activates) Kim et al., Mol Cell 2003*, von der Lehr et al., Mol Cell 2003*
  Evidence: mutant phenotype, assay, physical interaction
• WikiPathways Imatinib and Chronic Myeloid Leukemia: MYC → SKP2 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MYC — SKP2 (physical association, affinity chromatography technology) von der Lehr et al., Cell cycle (Georgetown, Tex.) 2003*
• IRef Biogrid Interaction: MYC — SKP2 (physical association, affinity chromatography technology) Zhang et al., Proc Natl Acad Sci U S A 2013*
• IRef Biogrid Interaction: MYC — SKP2 (physical association, affinity chromatography technology) von der Lehr et al., Mol Cell 2003*
• IRef Biogrid Interaction: MYC — SKP2 (direct interaction, pull down) von der Lehr et al., Mol Cell 2003*
• IRef Biogrid Interaction: MYC — SKP2 (direct interaction, protein complementation assay) von der Lehr et al., Mol Cell 2003*
• IRef Hprd Interaction: SKP2 — MYC (in vivo) Fujii et al., Mol Cell 2006*
• IRef Intact Interaction: MYC — SKP2 (physical association, anti bait coimmunoprecipitation) Fujii et al., Mol Cell 2006*

Text-mined interactions from Literome

Kim et al., Mol Cell 2003 (Cell Transformation, Neoplastic...) : Skp2 regulates Myc protein stability and activity
von der Lehr et al., Mol Cell 2003 : Surprisingly, Skp2 enhances c-Myc induced S phase transition and activates c-Myc target genes in a Myc dependent manner ... Moreover, Myc dependent association of Skp2 , ubiquitylated proteins, and subunits of the proteasome to a c-Myc target promoter was demonstrated in vivo
Bretones et al., J Biol Chem 2011 (Leukemia...) : Here we show that MYC induces SKP2 expression at the mRNA and protein levels in human myeloid leukemia K562 cells with conditional MYC expression ... MYC dependent SKP2 expression was also detected in other cell types such as lymphoid, fibroblastic, and epithelial cell lines ... MYC induced SKP2 mRNA expression in the absence of protein synthesis and activated the SKP2 promoter in luciferase reporter assays ... Finally, MYC induced SKP2 expression resulted in a decrease in p27 protein in K562 cells ... Our data show that SKP2 is a direct MYC target gene and that MYC mediated SKP2 induction leads to reduced p27 levels
Lee et al., J Cell Sci 2011 : Meanwhile, Romo1 expression induced by Myc during G1 phase stimulates Skp2 mediated Myc degradation in a negative-feedback mechanism