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BMI1 — MYC

Text-mined interactions from Literome

Huang et al., FASEB J 2011 (Neuroblastoma) : Overexpression of MYCN or MYC transactivated the BMI1 promoter and up-regulated BMI1 gene expression ... Our results indicate that MYCN and MYC regulate BMI1 gene expression at the transcriptional level and that dysregulation of the BMI1 gene mediated by MYCN or MYC overexpression, confers increased cell proliferation during neuroblastoma genesis and tumor progression
Wang et al., FEBS J 2013 (Carcinoma...) : Sp1 and c-Myc regulate transcription of BMI1 in nasopharyngeal carcinoma ... In addition, Myc , the known transcription factor for BMI1 in neuroblastomas, also activated the transcription of BMI1 through binding to the E-box element ( -181 ) within its promoter, and showed a positive correlation with the mRNA level of BMI1 in NPC ... In conclusion, these findings provide valuable mechanistic insights into the role of Sp1 and c-Myc in BMI1 transcription in NPC, and suggest that targeting of Sp1 or c-Myc may be a potential therapeutic strategy for NPC