Suzuki et al., Toxicol Pathol 2010
(Body Weight...) :
MeIQx is metabolically activated by CYP1A2 and then N-acetyltransferase (NAT) , findings that suggest that its carcinogenic potential might be enhanced by simultaneous exposure to chemical ( s ) inducing CYP1A2
Liu et al., Cancer Lett 1998
:
In sonicate from transiently transfected COS cells, NAT1 increased CYP1A2 catalyzed adduct formation 4-fold while NAT2 increased adduct formation 12-fold