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GRB10 — INSR

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: GRB10 → INSR (directlyIncreases, GRB10 Activity)
  Evidence: It also contains an additional binding site located in the phosphorylated kinase activation loop of the insulin receptor but is only very slightly phosphorylated by insulin receptor.
• NCI Pathway Database Insulin Pathway: GRB10 (GRB10) → Insulin Receptor/Insulin/SHC complex (INSR-INS-SHC1) (modification, collaborate)
  O'Neill et al., J Biol Chem 1996, Dong et al., Mol Endocrinol 1997*
  Evidence: physical interaction
• NCI Pathway Database Insulin Pathway: GRB10 (GRB10) → Insulin Receptor/Insulin/SHC/GRB10 complex (INSR-INS-SHC1-GRB10) (modification, collaborate)
  O'Neill et al., J Biol Chem 1996, Dong et al., Mol Endocrinol 1997*
  Evidence: physical interaction
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insulin/SHC complex (INSR-INS-SHC1) → Insulin Receptor/Insulin/SHC/GRB10 complex (INSR-INS-SHC1-GRB10) (modification, collaborate)
  O'Neill et al., J Biol Chem 1996, Dong et al., Mol Endocrinol 1997*
  Evidence: physical interaction
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insulin/SHC/GRB10 complex (INSR-INS-SHC1-GRB10) → p62DOK (DOK1) (modification, inhibits) Wick et al., J Biol Chem 2001
  Evidence: assay
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insulin/SHC/GRB10 complex (INSR-INS-SHC1-GRB10) → Insulin Receptor/Insulin/SHC/GRB2/Sos1 complex (INSR-INS-SHC1-GRB2-SOS1) (modification, inhibits)
  Wick et al., J Biol Chem 2001
  Evidence: assay
• Reactome Reaction: GRB10 → INSR (indirect_complex) Wick et al., J Biol Chem 2003*, Langlais et al., Mol Endocrinol 2004*
• Reactome Reaction: GRB10 → INSR (reaction) Wick et al., J Biol Chem 2003*, Langlais et al., Mol Endocrinol 2004*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: GRB10 — INSR He et al., J Biol Chem 1998
• IRef Bind_translation Interaction: GRB10 — INSR (affinity chromatography technology) He et al., J Biol Chem 1998
• IRef Bind_translation Interaction: GRB10 — INSR (two hybrid) He et al., J Biol Chem 1998
• IRef Biogrid Interaction: GRB10 — INSR (direct interaction, two hybrid) Hansen et al., J Biol Chem 1996*
• IRef Biogrid Interaction: GRB10 — INSR (direct interaction, pull down) Hansen et al., J Biol Chem 1996*
• IRef Biogrid Interaction: GRB10 — INSR (physical association, affinity chromatography technology) Hansen et al., J Biol Chem 1996*
• IRef Biogrid Interaction: GRB10 — INSR (direct interaction, two hybrid) Liu et al., Proc Natl Acad Sci U S A 1995*
• IRef Biogrid Interaction: GRB10 — INSR (physical association, affinity chromatography technology) Liu et al., Proc Natl Acad Sci U S A 1995*
• IRef Biogrid Interaction: GRB10 — INSR (direct interaction, pull down) Liu et al., Proc Natl Acad Sci U S A 1995*
• IRef Biogrid Interaction: GRB10 — INSR (direct interaction, two hybrid) He et al., J Biol Chem 1998
• IRef Biogrid Interaction: GRB10 — INSR (direct interaction, pull down) He et al., J Biol Chem 1998
• IRef Biogrid Interaction: GRB10 — INSR (physical association, affinity chromatography technology) Frantz et al., J Biol Chem 1997*
• IRef Biogrid Interaction: GRB10 — INSR (physical association, affinity chromatography technology) Mori et al., Mol Cell Endocrinol 2005*
• IRef Biogrid Interaction: GRB10 — INSR (physical association, affinity chromatography technology) Langlais et al., Oncogene 2000*
• IRef Dip Interaction: GRB10 — INSR (physical association, anti bait coimmunoprecipitation) Depetris et al., Nature structural & molecular biology 2009*
• IRef Hprd Interaction: GRB10 — INSR (in vitro) Wick et al., J Biol Chem 2003*, Liu et al., Proc Natl Acad Sci U S A 1995*, Hansen et al., J Biol Chem 1996*, He et al., J Biol Chem 1998
• IRef Hprd Interaction: GRB10 — INSR (two hybrid) Wick et al., J Biol Chem 2003*, Liu et al., Proc Natl Acad Sci U S A 1995*, Hansen et al., J Biol Chem 1996*, He et al., J Biol Chem 1998
• IRef Hprd Interaction: GRB10 — INSR (in vivo) Wick et al., J Biol Chem 2003*, Liu et al., Proc Natl Acad Sci U S A 1995*, Hansen et al., J Biol Chem 1996*, He et al., J Biol Chem 1998
• IRef Innatedb Interaction: GRB10 — INSR (unknown, -) Wick et al., J Biol Chem 2003*
• IRef Intact Interaction: GRB10 — INSR (direct interaction, pull down) He et al., J Biol Chem 1998
• IRef Intact Interaction: GRB10 — INSR (physical association, protein three hybrid) He et al., J Biol Chem 1998
• IRef Intact Interaction: GRB10 — INSR (physical association, two hybrid) He et al., J Biol Chem 1998
• IRef Ophid Interaction: GRB10 — INSR (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: GRB10 — INSR (aggregation, confirmational text mining) Hansen et al., J Biol Chem 1996*

Text-mined interactions from Literome