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IL6 — RAG1
Text-mined interactions from Literome
Hillion et al., Autoimmun Rev 2007
(Autoimmune Diseases) :
Peripheral expression of
RAG in human B lymphocytes in normal and pathological conditions is
dependent on
interleukin-6
Rochas et al., Arthritis Rheum 2009
(Arthritis, Rheumatoid...) :
Transmembrane BAFF from rheumatoid synoviocytes requires
interleukin-6 to
induce the expression of
recombination activating gene in B lymphocytes
Yan et al., J Autoimmun 2012
:
Diminishing
IL-6 by blocking antibody or haplo-insufficiency
leads to reduced expression of the IL-7 receptor and
RAG and increased titers of anti-DNA antibodies following immunization with a peptide mimetope of DNA
Tagoh et al., Blood 1996
:
Among recombinant cytokines,
interleukin-3 (IL-3), IL-6, and IL-7, but not IL-2, IL-4, stem cell factor (SCF), and granulocyte-macrophage colony stimulating factor ( GM-CSF ) could
induce RAG-1 activation in FL8.2.4.4 cells, and a significant synergistic effect between IL-3, IL-6, and IL-7 was observed
Muraguchi et al., Leukemia & lymphoma 1998
:
Among the cytokines, IL-3,
IL-6 , and IL-7, but not IL-2, IL-4, SCF, GM-CSF
induces RAG activation