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IL17F — IL6
Text-mined interactions from Literome
Yagi et al., J Gastroenterol 2007
(Colitis) :
IL-17A and
IL-17F significantly
enhanced IL-6 , IL-8, LIF, MMP-1, and MMP-3 secretion ... Both IL-17A and
IL-17F augmented IL-1beta induced secretion of
IL-6 , IL-8, LIF, MMP-1, and MMP-3 ... Inhibitors for ERK ( PD98059 and U0216 ) and p38 MAPK ( SB203580 ) significantly reduced the
IL-17F induced
IL-6 , IL-8, LIF, MMP-1, and MMP-3 secretion
Cheung et al., J Immunol 2008
(Inflammation) :
IL-17A,
IL-17F , and IL-23 could
induce the release of chemokines GRO-alpha/CXCL1, IL-8/CXCL8, and MIP-1beta/CCL4 from eosinophils, while IL-17F and IL-23 could also increase the production of proinflammatory cytokines IL-1beta and
IL-6
Mus et al., Arthritis Rheum 2010
(Arthritis, Experimental) :
In contrast, transforming growth factor beta1 ( TGFbeta1 )
/IL-6 was a potent
inducer of RORgammat, RORalpha, IL-17A,
IL-17F , IL-21, and FoxP3 in these cells
Fujishima et al., Arch Dermatol Res 2010
(Psoriasis) :
The results showed that
IL-17F induced production of
IL-6 in NHEKs in a time dependent manner ... Our results indicate that
IL-17F produced by CD4 ( + ) T cells
causes the inflammation in psoriasis partly through induction of
IL-6 in keratinocytes