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EPO — IL6
Text-mined interactions from Literome
Fandrey et al., Ann N Y Acad Sci 1991
(Carcinoma, Hepatocellular...) :
A dose dependent decrease of up to 60 % in
Epo production was
induced by interleukin-1 beta,
interleukin-1 alpha, and tumor necrosis factor-alpha ( in that order of potency )
Ghinassi et al., Exp Hematol 2007
:
These results suggest that interleukin-3 and erythropoietin cooperate to establish the lineage-specific transcription factor milieu of erythroid cells
: interleukin-3 regulates mainly gene transcription and
erythropoietin consistently
increases mRNA and protein stability
Ramadori et al., Lab Invest 2010
(Acute-Phase Reaction...) :
Cellular and molecular mechanisms
regulating the hepatic
erythropoietin expression during acute-phase response : a role for
IL-6
Bian et al., Neurol Med Chir (Tokyo) 2010
(Brain Injuries...) :
Effect of recombinant human
erythropoietin on serum S100B protein and
interleukin-6 levels after traumatic brain injury in the rat
Lifshitz et al., Haematologica 2010
:
The macrophages derived in-vitro from bone marrow cells expressed erythropoietin receptor transcripts, and in-vitro stimulation with
erythropoietin activated multiple signaling pathways, including signal transducer and activator of transcription ( STAT ) 1 and 5, mitogen activated protein kinase, phosphatidylinositol 3-kinase and nuclear factor kappa B. In-vitro erythropoietin treatment of these cells up-regulated their surface expression of CD11b, F4/80 and CD80, enhanced their phagocytic activity and nitric oxide secretion, and also
led to augmented
interleukin 12 secretion and decreased interleukin 10 secretion in response to lipopolysaccharide
Cervellini et al., J Biol Regul Homeost Agents 2013
(Necrosis) :
Erythropoietin does not
affect TNF and
IL-6 production directly
Poloni et al., Boll Soc Ital Biol Sper 1997
:
Epo in
presence of SCF+ IL3+
IL6+/-FL dramatically increased total cell expansion ( 2300-2800-fold ), mainly erythroblastic ( 70 % glycoA ) without exhaustion of all other compartments