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IL12A — SPP1
Text-mined interactions from Literome
O'Regan et al., J Leukoc Biol 2000
:
These findings suggest a functional
role for
osteopontin in early Th1 responses, namely regulation of T cell dependent
IL-12 production
Koguchi et al., Infect Immun 2002
(AIDS-Related Opportunistic Infections) :
We investigated the
role of
osteopontin (OPN) in
interleukin-12 (IL-12) production from peripheral blood mononuclear cells ( PBMCs ) stimulated with Penicillium marneffei ... Furthermore, native
OPN induced a profound level of synthesis of
IL-12 from noninfected PBMCs ... Our results demonstrated that
OPN secreted from monocytes is
involved in the production of
IL-12 from PBMCs after stimulation with P. marneffei and that OPN production is regulated by GM-CSF
Koguchi et al., Am J Respir Crit Care Med 2003
(Sarcoidosis, Pulmonary...) :
In vitro experiments showed that
OPN production by peripheral blood mononuclear cells infected with Mycobacterium bovis bacillus Calmette-Guérin preceded the synthesis of IL-12 and interferon-gamma and that the neutralizing anti-OPN monoclonal antibody significantly
reduced the production of
IL-12 and interferon-gamma
Morimoto et al., Int Immunol 2004
(Drug-Induced Liver Injury...) :
Second,
OPN deficiency
resulted in the reduction of
IL-12 and IFN-gamma production at early stages
Renkl et al., Blood 2005
:
OPN induces their Th1 promoting tumor necrosis factor alpha (TNF-alpha) and
interleukin-12 (IL-12) secretion, and enhances their allostimulatory capacity
Sato et al., Gut 2005
(Colitis, Ulcerative...) :
Recent studies have shown that
OPN plays an important role in lymphocyte migration, granuloma formation, and
interleukin 12 (IL-12) production ...
OPN induced production of
IL-12 from LPMC in CD but not in normal controls or UC