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IFNG — SLC26A3
Text-mined interactions from Literome
Spilianakis et al., EMBO J 2003
:
We describe the temporal order of recruitment of transcription factors, cofactors and basal transcriptional components and the consequent biochemical events that lead to
activation of the major histocompatibility class II ( MHCII )
DRA gene transcription by
IFN-gamma
Moses et al., J Immunol 1992
(Glioma) :
The correlation of the functional importance of X1 in
IFN-gamma regulated
DRA expression and the enhancement of IFNEX by IFN-gamma strongly suggests that IFNEX may play a crucial role in IFN-gamma regulated class II MHC gene expression
Giorda et al., FEBS J 2005
:
The same fragment, however, did not efficiently direct
IFN-gamma induced
DRA expression in macrophages, that required additional 5 ' sequences
Alrefai et al., Am J Physiol Gastrointest Liver Physiol 2007
(Adenoma) :
We also demonstrated a reduction in DRA promoter activity in Caco-2 cells by IFN-gamma, suggesting that
regulation of
DRA promoter by
IFN-gamma may contribute to the pathophysiology of intestinal inflammation
Castelli et al., Exp Clin Immunogenet 1991
(Melanoma) :
Recombinant
interferon-gamma differently
affects DQA and
DRA gene expression in two human melanoma clones : transcriptional and posttranscriptional regulation
Devajyothi et al., J Biol Chem 1993
(Astrocytoma) :
To address mechanisms by which cytokines inhibit interferon-gamma (IFN gamma) induced gene expression in astrocytic cells, we have been studying effects of type beta 1 transforming growth factor ( TGF beta 1 ) and interferon-beta (IFN beta) on
IFN gamma induced expression of the well characterized human major histocompatibility complex ( MHC) class II gene
DRA ... We previously showed that IFN beta inhibited
IFN gamma induced
DRA expression at the transcriptional level ... To address the mechanism of this inhibition, sequence requirements for IFN beta and TGF beta 1 to suppress
IFN gamma induced transcription of
DRA were determined ... These experiments suggested that either IFN beta or TGF beta 1 could repress
IFN gamma induced
DRA transcription directly, without requiring a cis-element extrinsic to the IFN gamma-inducible DRA sequences ... These data argued that IFN beta and TGF beta 1 utilized distinct pathways to mediate the inhibition of
IFN gamma induced
DRA transcription