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FYN — IL11

Text-mined interactions from Literome

Wang et al., J Biol Chem 1995 : Interleukin-11 induces complex formation of Grb2, Fyn , and JAK2 in 3T3L1 cells ... JAK2 and Fyn are transiently associated with Grb2 upon stimulation with IL-11 , suggesting that JAK2 and Fyn may be involved in transducing signals from the IL-11 receptor-glycoprotein 130 to the Ras system through Grb2 ... Taken together, these results suggest that IL-11 induced interactions of JAK2, Fyn , and Grb2 may not only provide a novel mechanism for the activation of the Ras/MAPK system but also indicate cross-talk among diverse signaling pathways
Fuhrer et al., Exp Hematol 1996 : To summarize, IL-11 activates p60src, p62yes and PI3K but not p59fyn , and this activation of p62yes leads to its association with PI3K and PI3K activation