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EGFR — IL8

Text-mined interactions from Literome

Venkatakrishnan et al., J Biol Chem 2000 (Ovarian Neoplasms) : Of note, IL-8 induced transient phosphorylation of the epidermal growth factor (EGF) receptor and its association with the adaptor molecules Shc and Grb2
Bancroft et al., Int J Cancer 2002 (Carcinoma, Squamous Cell...) : We conclude that antagonists of EGFR, PI3K and MEK signal pathways have inhibitory activity against EGFR induced NF-kappaB and AP-1 activation, IL-8 and VEGF expression and growth by HNSCC
Hamilton et al., Clin Exp Allergy 2003 (Asthma...) : Using H292 cells, EGF and H2O2 increased IL-8 gene expression and release and this was completely suppressed by the EGFR-selective tyrosine kinase inhibitor, AG1478, but only partially by dexamethasone ... These results suggest that in severe asthma, epithelial damage has the potential to contribute to neutrophilic inflammation through enhanced production of IL-8 via EGFR- dependent mechanisms
Tanida et al., Gastroenterology 2004 (Stomach Neoplasms) : KB-R7785 completely blocked IL-8 induced shedding and EGFR transactivation ... Depletion of ADAM10 also dramatically reduced IL-8 induced shedding and EGFR transactivation, but depletion of ADAM12 and 17 did not
Itoh et al., Cytokine 2005 (Carcinoma...) : IL-8 transiently induced EGFR tyrosine phosphorylation after 5-90 min and this was completely inhibited by ADAM inhibitor
Joh et al., Dig Dis Sci 2005 : IL-8 also induced EGFR phosphorylation, while anti-IL-8 and anti-IL-8 receptor ( CXCR1 ) neutralizing antibodies suppressed EGFR phosphorylation
Chokki et al., Life Sci 2006 : Since recent studies demonstrated that the stimulation of epidermal growth factor receptor (EGFR) could induce IL-8 secretion, the involvement of EGFR in TNF-alpha induced IL-8 secretion in airway epithelium-like NCI-H292 cells was investigated in this study ... Inhibition of the EGFR by either an anti-EGFR neutralizing antibody or by its specific inhibitor AG1478 ( 1 microM ) blocked TNF-alpha induced IL-8 secretion ... These findings indicate that metalloprotease mediated AR shedding and subsequent activation of EGFR play a critical role in TNF-alpha induced IL-8 secretion from the human airway epithelium-like NCI-H292 cells, and that TACE is one of the most possible candidates for metalloprotease responsible for TNF-alpha induced AR shedding
Zhao et al., J Biol Chem 2006 : Furthermore, down-regulation of EGFR by EGFR small interfering RNA or pretreatment of cells with EGFR inhibitors AG1478 and PD158780 almost completely blocked LPA dependent EGFR phosphorylation and partially attenuated IL-8 secretion, respectively ... These results demonstrate that LPA induced IL-8 secretion is partly dependent on EGFR transactivation regulated by PKCdelta dependent activation of Lyn kinase and MMPs and proHB-EGF shedding, suggesting a novel mechanism of cross-talk and interaction between G-protein coupled receptors and receptor-tyrosine kinases in HBEpCs
Liu et al., J Biol Chem 2008 (Asthma...) : The EGFR inhibitor AG1478, completely blocked IL-8 and ICAM-1 expression to basal levels, as did the specific Erk1/2 inhibitor U0126
Beswick et al., Infect Immun 2008 : Macrophage migration inhibitory factor and interleukin-8 produced by gastric epithelial cells during Helicobacter pylori exposure induce expression and activation of the epidermal growth factor receptor ... MIF and IL-8 also induced phosphorylation of EGFR , signaling events, and proliferation during H. pylori exposure, all of which were decreased when they were neutralized by these cytokines or were blocked from their receptors
Boots et al., J Biol Chem 2009 : Both ADAM17 activation and IL-8 release were suppressed by inhibitors of EGFR/ERK1/2 signaling, which can regulate ADAM17 activity by serine/threonine phosphorylation
Wu et al., J Neurosurg 2010 (Brain Injuries...) : Simvastatin modified the caveolin-1 expression in lipid rafts in astrocyte cell membrane, suppressed the phosphorylation of EGFR in lipid rafts of astrocytes after OGD, and inhibited the OGD induced interleukin-1 production
Zhang et al., J Cell Physiol 2012 (Carcinoma, Non-Small-Cell Lung...) : EGF stimulated IL-8 production, phosphorylation of Akt and Erk, and cell proliferation and movement could be inhibited by EGFR inhibitor ( Erlotinib ), PI3K inhibitor ( GDC-0941 BEZ-235 and SHBM1009 ), and ERK1/2 inhibitor ( PD98059 )
Breshears et al., J Biol Chem 2012 : EGFR signaling is critical for up-regulation of IL-8 at the transcriptional level in response to TSST-1 and is also necessary for AREG, TGFa, and TNFR1 shedding
Singh et al., Clin Cancer Res 2013 (Breast Neoplasms...) : IL-8 induced activation of EGFR/HER2 and downstream signaling pathways and effects were abrogated by inhibition of SRC, EGFR/HER2, phosphoinositide 3-kinase (PI3K), or MEK