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EGFR — HGF
Pathways - manually collected, often from reviews:
-
KEGG Focal adhesion:
EGF/FIGF/HGF/IGF1/PDGFA/PDGFB/PDGFC/PDGFD/PGF/VEGFA/VEGFB/VEGFC
→
EGFR/ERBB2/FLT1/FLT4/IGF1R/KDR/MET/PDGFRA/PDGFRB
(protein-protein, activation)
-
KEGG Melanoma:
EGF/FGF1/FGF10/FGF11/FGF12/FGF13/FGF14/FGF16/FGF17/FGF18/FGF19/FGF2/FGF20/FGF21/FGF22/FGF23/FGF3/FGF4/FGF5/FGF6/FGF7/FGF8/FGF9/HGF/IGF1/PDGFA/PDGFB/PDGFC/PDGFD
→
EGFR/FGFR1/IGF1R/MET/PDGFRA/PDGFRB
(protein-protein, activation)
-
WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway:
EFNA1/FGF1/FGF11/FGF10/EFNA2/EGF/FGF12/CSF1/ANGPT4/ANGPT2/ANGPT1/VEGFA/EFNA3/EFNA4/EFNA5/FGF14/FGF19/FGF17/FGF18/FGF2/FGF3/FGF4/FGF6/FGF7/FGF8/FGF9/FIGF/HGF/IGF1/INS/INS/KITLG/VEGFC/VEGFB/PDGFB/PGF/PDGFA/NGF/PDGFC/FGF21/FGF22/PDGFD/FGF20/FGF16
→
FGFR2/KDR/INSR/FGFR3/IGF1R/KIT/FGFR1/EPHA2/EGFR/CSF1R/FGFR4/FLT1/FLT4/NGFR/MET/PDGFRA/PDGFRB/TEK
(activation)
-
WikiPathways Focal Adhesion:
EGF/FIGF/HGF/IGF1/PDGFA/PDGFB/PGF/PDGFC/PDGFD/VEGFA/VEGFB/VEGFC
→
BLK/EGFR/ERBB2/FGR/FLT1/HCK/IGF1R/KDR/MET/PDGFRA/PDGFRB/PTK6/SRMS/TXK/TESK2/STYK1/TNK2/TNK1
(activation)
Text-mined interactions from Literome
Xu et al., Invest Ophthalmol Vis Sci 2007
:
HGF also
induced EGFR tyrosine phosphorylation ... The EGFR kinase inhibitor AG1478 blocked wound- and
HGF stimulated
EGFR transactivation and attenuated spontaneous and growth factor induced wound closure
Bonine-Summers et al., Cancer Biol Ther 2007
(Breast Neoplasms...) :
Epidermal growth factor receptor plays a significant role in
hepatocyte growth factor mediated biological responses in mammary epithelial cells ... In the present study it was shown that the
epidermal growth factor receptor (EGFR) plays a significant role in
HGF/c-Met mediated biological activities indicative of advanced tumor pathology, including enhanced proliferation and invasion ... Our analyses indicated that
EGFR inhibition significantly
blocked HGF activation of c-Met and EGFR and that inhibition of these pathways mitigated HGF induced proliferation and motility
Siegfried et al., Mol Pharmacol 2007
(Carcinoma, Non-Small-Cell Lung...) :
The addition of PGE ( 2 ) to NSCLC cells also led to rapid phosphorylation of c-Met in the absence of
HGF , which was
blocked by
epidermal growth factor receptor (EGFR) inhibition
Spix et al., Exp Cell Res 2007
:
Early after HGF stimulation, blocking
EGFR activation does not
inhibit extracellular-signal regulated kinase 1/2 ( ERK1/2 ) activation by
HGF , but the converse is seen after approximately 1 h, indicating the existence of EGFR dependent and -independent routes of ERK1/2 activation
Brevet et al., J Thorac Oncol 2011
(Mesothelioma...) :
Conversely, stimulation with
hepatocyte growth factor increased both phospho-MET and
phospho-EGFR
Shimizu et al., Arterioscler Thromb Vasc Biol 2012
(Disease Models, Animal...) :
HGF inhibited the increase in the expression of vascular cell adhesion molecule-1 and
EGFR by LPS in vitro
Gusenbauer et al., Oncogene 2013
(Neoplasms) :
However, only little is known about the
HGF/Met induced
EGFR TKI resistance mechanism in other human cancer types
Kang et al., Evidence-based complementary and alternative medicine : eCAM 2013
:
Our studies showed that bufalin could reverse resistance to reversible and irreversible
EGFR-TKIs induced by exogenous
HGF in EGFR mutant lung cancer cells by inhibiting the Met/PI3K/Akt pathway and inducing death signaling