Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
CXCL8
→
IL18
(increases)
Evidence: IL-18 can act in synergy with IL-12 in regulating IFN-g (18). However, IL-18 also up-regulates other cytokines, such as TNF-a, IL-1b, and IL-8 in non-CD141 PBMCs, resting T cells, and NK cells (19). IL-18 up-regulates GM-CSF in PBMCs (20) and also in synovial membrane cultures, directly affecting macrophages to stimulate cytokine production (21).
OpenBEL Selventa BEL large corpus:
CXCL8
→
IL18
(increases)
Evidence: IL-18 is also ascribed many inflammatory functions that would be consistent with a role in angiogenesis. For instance, IL-18 stimulates the production of other proangiogenic cytokines, such as TNF-a, IL-1b and IL-8, from human PBMCs, the responding cells being predominantly resting T cells and NK cells. IL-18 stimulation of the chemokine IL-8 has also been shown in the macrophage cell line derived from histiocytic lymphoma cell, U937, and the myelomonocytic leukemia cell line, KG-1 (44, 45), to...