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CDC25B — MAPKAPK2

Pathways - manually collected, often from reviews:

• NCI Pathway Database p38 signaling mediated by MAPKAP kinases: p38alpha-beta/MAPKAPK2 complex (MAPK14_MAPK11-MAPKAPK2) → CDC25B (CDC25B) (modification, activates) Bulavin et al., Nature 2001, Manke et al., Mol Cell 2005
  Evidence: mutant phenotype, assay

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: CDC25B — MAPKAPK2 (experimental interaction detection) Manke et al., Mol Cell 2005
• IRef Biogrid Interaction: MAPKAPK2 — CDC25B (direct interaction, enzymatic study) Manke et al., Mol Cell 2005

Text-mined interactions from Literome

Manke et al., Mol Cell 2005 : We show that MAPKAP kinase-2 is directly responsible for Cdc25B/C phosphorylation and 14-3-3 binding in vitro and in response to UV-induced DNA damage within mammalian cells
Reinhardt et al., Mol Cell 2010 (Head and Neck Neoplasms) : Gadd45a functions within a positive feedback loop, sustaining the MK2 dependent cytoplasmic sequestration of Cdc25B/C to block mitotic entry in the presence of unrepaired DNA damage