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CD4 — PTPRC

Pathways - manually collected, often from reviews:

• Reactome Reaction: PTPRC → CD4 (reaction) Leo et al., J Clin Invest 2002

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PTPRC — CD4 (direct interaction, fluorescent resonance energy transfer) Mittler et al., J Immunol 1991*
• IRef Hprd Interaction: PTPRC — CD4 (in vivo) Mittler et al., J Immunol 1991*
• IRef Ophid Interaction: PTPRC — CD4 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: PTPRC — CD4 (aggregation, confirmational text mining) Mittler et al., J Immunol 1991*

Text-mined interactions from Literome

Steingrimsdottir et al., Haematologica 2000 (Bone Marrow Diseases...) : The low number of CD4 ( + ) cells was due to a persistently low level of naive CD4 ( + ) CD45RA ( + ) cells
Schlüter et al., J Immunol 2002 (Encephalitis...) : During progression from acute to chronic TE, both CD4 and CD8 T cells down-regulated CD45RB expression and expressed a differential pattern of cytokines
Demir et al., Leuk Res 2003 (Melanoma...) : Expression of CD95 ( Apo-1/Fas ) and CD45RO on monocytes increased significantly on the 5th day, and CD4 expression on monocytes increased significantly on the 14th day
Kanai et al., J Immunol 2003 (Chronic Disease...) : We first examined the expression profiles of PD-1 and its ligands in both human inflammatory bowel disease and a murine chronic colitis model induced by adoptive transfer of CD4 ( + ) CD45RB ( high ) T cells to SCID mice
Trebichavský et al., Folia Biol (Praha) 1992 : CD5, CD15 and CD45 antigens were detected at 6 weeks of gestation, whereas CD4 , CD8, CD10, CD11c, CD14 and IgM were not expressed at this stage
Harari et al., Eur J Immunol 2004 (Cytomegalovirus Infections...) : Multi-phenotypic CD45RA ( - ) CCR7 ( + ), CD45RA ( - ) CCR7 ( - ) and CD45RA ( + ) CCR7 ( - ) CD4 T cell responses were associated with protracted Ag exposure and low load ( chronic CMV, EBV and HSV infections and HIV-1 infection in long-term nonprogressors )
Leitenberg et al., Immunology 2007 : In the present study we have examined the role of the transmembrane adapter-like molecule CD45 associated protein (CD45-AP) in regulating the association of CD45 with CD3/TCR and lck, and in regulating primary CD4 ( + ) T-lymphocyte activation
Salmond et al., Int Immunol 2008 : The data demonstrate that expression of CD45RB or CD45RABC at intermediate levels also results in CD4 ( + ) T cell hyper-reactivity, as previously published for CD45RO
Tomita et al., Inflamm Bowel Dis 2008 (Chronic Disease...) : Third, CD4 ( + ) cells in parabionts between established colitic RAG-2 ( -/- ) mice induced by adoptive transfer of Ly5.1 ( + ) or Ly5.2 ( + ) CD4 ( + ) CD45RB ( high ) T cells were well mixed in almost equal proportions at various sites 2 weeks after parabiosis surgery, and the redistribution of Ly5.1 ( + ) and Ly5.2 ( + ) CD4 ( + ) T cells was significantly suppressed in FTY720 treated parabionts
Thurston et al., Gastroenterology 2010 (Colitis...) : We studied 3 mouse models of IBD : colitis induced by trinitrobenzene sulfonic acid, colitis induced by microflora ( in gnotobiotic interleukin-10 ( -/- ) ), and colitis induced by adoptive transfer of CD4 ( + ) CD45RB ( high ) T cells
Baba et al., Int Immunol 2010 (Autoimmune Diseases) : We found that CD45RA ( + ) Treg promoted while TNF-alpha inhibited naive CD4 ( + ) T-cell differentiation into IL-17 and CCL20 co-expressing T ( h ) 17 cells without influencing their IL-22 release
Yamazaki et al., Hum Immunol 2013 (Angiolymphoid Hyperplasia with Eosinophilia) : Increased CD45RO ( + ) CD62L ( + ) CD4 ( + ) T-cell subpopulation responsible for Th2 response in Kimura 's disease
Papo et al., J Rheumatol 1994 (Antiphospholipid Syndrome) : Blood lymphocytes counts, proportions of B cells ( CD19+ ), total CD5 and CD5 B cells, NK cells ( CD16+CD56+ ), T cells ( CD3+ ), CD4+ helper ( naive CD4+CD45RA+ , memory CD4+CD45RO+ and CD4+CD29+, activated CD4+CD25+ ), CD8 ( immunoregulatory CD8+CD57+, activated CD8+HLA-DR+ ) T cell subsets were measured by flow cytometry analysis
Ross et al., Biochem Biophys Res Commun 1994 : The association between CD45 and lck does not require CD4 or CD8 and is independent of T cell receptor stimulation
Ledbetter et al., Curr Opin Immunol 1993 : CD4 , CD8 and CD45 regulate the coupling of the T-cell receptor complex ( CD3-TCR ) to tyrosine kinase activation and phosphorylation of key substrates such as phospholipase C gamma 1