Gene interactions and pathways from curated databases and text-mining

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CD4 — ICOS

Text-mined interactions from Literome

Kopf et al., J Exp Med 2000 : Together, our results demonstrate that ICOS regulates both CD28 dependent and CD28 independent CD4 ( + ) subset ( Th1 and Th2 ) responses but not CTL responses in vivo
Vidric et al., J Immunol 2005 : In support of this hypothesis, we found that anti-4-1BB enhances ICOS expression on both T cell subsets and that anti-4-1BB and anti-ICOS can synergistically activate CD4 and CD8 T cells
Elyaman et al., Am J Pathol 2008 (Encephalomyelitis, Autoimmune, Experimental) : We found that memory CD4 ( + ) T cells up-regulated the activation marker CD44 as well as CXCR3 and ICOS , proliferated more and produced more interferon-gamma and less interleukin-17 compared to effector T cells
Kadkhoda et al., J Immunol 2010 (Chlamydia Infections...) : Finally, we showed that ICOS-ICOSL interaction and cell-cell contact are essential for CD4 ( + ) T cells to inhibit chlamydial growth in the cultured lung fibroblasts