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CD4 — ICOS
Text-mined interactions from Literome
Kopf et al., J Exp Med 2000
:
Together, our results demonstrate that
ICOS regulates both CD28 dependent and CD28 independent
CD4 ( + ) subset ( Th1 and Th2 ) responses but not CTL responses in vivo
Vidric et al., J Immunol 2005
:
In support of this hypothesis, we found that anti-4-1BB enhances ICOS expression on both T cell subsets and that anti-4-1BB and
anti-ICOS can synergistically
activate CD4 and CD8 T cells
Elyaman et al., Am J Pathol 2008
(Encephalomyelitis, Autoimmune, Experimental) :
We found that memory
CD4 ( + ) T cells
up-regulated the activation marker CD44 as well as CXCR3 and
ICOS , proliferated more and produced more interferon-gamma and less interleukin-17 compared to effector T cells
Kadkhoda et al., J Immunol 2010
(Chlamydia Infections...) :
Finally, we showed that
ICOS-ICOSL interaction and cell-cell contact are
essential for
CD4 ( + ) T cells to inhibit chlamydial growth in the cultured lung fibroblasts